Results 31 to 40 of about 75,155 (200)
Frontiers in Immunology, 2022 Gamma-delta (γδ) T cells recognize antigens in a major histocompatibility complex (MHC) independent and have cytotoxic capability. Human immunodeficiency virus (HIV) infection reduces the proportion of the Vδ2 cell subset compared to the Vδ1 cell subset ...
Shivkumar Biradar +6 more
doaj +1 more source
Frontiers in Genetics, 2022 Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the GBA1 gene, which produces the glucocerebrosidase (GCase) protein. There are more than 500 mutations reported in GBA1, among which L444P (p.Leu444Pro) and
Jia-ni Guo +8 more
doaj +1 more source
Human Leprosy in Normal Mice [PDF]
BMJ, 1969 It has now been shown that normal mice can be used as models for studying the early stages in the development of leprosy. Inoculation into the foot pads of mice of as few as 10 4 leprosy bacilli leads to infections which spread to distant sites via the blood stream and after two or more years
R J, Rees +3 more
openaire +2 more sources
Humanized Mice in Dermatology Research [PDF]
Journal of Investigative Dermatology, 2015 INTRODUCTION The term “humanized mice” refers to immunodeficient mice containing human cells or tissues or to mice (immunodeficient or not) that have been genetically modified to express human genes. Humanized mouse models are increasingly utilized in many areas of research, such as infectious disease, autoimmune disease, cancer biology, and drug ...
Griffin, Russell L. +2 more
openaire +2 more sources
Immunity, Inflammation and Disease, 2020 Introduction Models of mice carrying a human immune system, so‐called humanized mice, are used increasingly as preclinical models to bridge the gap between model organisms and human beings. Challenges of the humanized mouse model include finding suitable
Lia Walcher +6 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2020 Background Well-characterized preclinical models are essential for immune-oncology research. We investigated the feasibility of our humanized mouse model for evaluating the long-term efficacy of immunotherapy and biomarkers.Methods Humanized mice were ...
Yong Wha Moon +12 more
doaj +1 more source
Generation and expression analysis of BAC humanized mice carrying HLA‐DP401 haplotype
Animal Models and Experimental Medicine, 2021 Background Human leukocyte antigen (HLA)‐DP is much less studied than other HLA class II antigens, that is, HLA‐DR and HLA‐DQ, etc. However, the accumulating data have suggested the important roles of DP‐restricted responses in the context of cancer ...
Feng Li +9 more
doaj +1 more source
Mice Are Not Humans: The Case of p53 [PDF]
Trends in Cancer, 2021 Mouse models represent powerful tools in cancer research that have influenced much of our understanding of tumor development and our current anticancer strategies. Yet, central signaling pathways differ considerably between mouse and human, including gene regulatory networks (GRNs) of the most important tumor suppressor p53 and its oncogenic sibling ...
openaire +2 more sources
Frontiers in Immunology, 2020 Asthma is a chronic airway disease often due to sensitization to aeroallergens, especially house dust mite allergens (HDMs). The Dermatophagoides pteronyssinus group 2 (Der p 2), is one of the most representative HDM allergens and is recognized by more ...
Martin Klein +10 more
doaj +1 more source
Frontiers in MicrobiomesHumanized mice with human-like immune systems are commonly used to study immune responses to human-specific pathogens. However, one limitation of using humanized mice is their native murine gut microbiota, which significantly differs from that in humans.
Lance Daharsh +7 more
doaj +1 more source