Results 41 to 50 of about 75,155 (200)

Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1

Molecular Therapy: Methods & Clinical Development, 2018
Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models.
Wannisa Khamaikawin, Saki Shimizu, Masakazu Kamata, Ruth Cortado, Yujin Jung, Jennifer Lam, Jing Wen, Patrick Kim, Yiming Xie, Sanggu Kim, Hubert Arokium, Angela P. Presson, Irvin S.Y. Chen, Dong Sung An   +13 more
doaj   +1 more source

Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

, 2012
Background: Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis.
Uwe Ritter (130470), Schmid, Maximilian, Hanses Frank, Ulrike Schleicher (104689), Frank Hanses, Maximilian Schmid, Florian, Christian, Frank Hanses (148604), Zimara Nicole, Wolfgang Ernst (13060), Wege, Anja Kathrin, Anja Kathrin Wege, Anja Kathrin Wege (148586), Christian Florian, Ernst, Wolfgang, Uwe Ritter, Hanses, Frank, Maximilian Schmid (148609), Florian Christian, Ritter Uwe, Nicole Zimara (148595), Zimara, Nicole, Christian Florian (148590), Schleicher, Ulrike, Ritter, Uwe, Nicole Zimara, Ernst Wolfgang, Schmid Maximilian, Schleicher Ulrike, Wege Anja Kathrin, Wolfgang Ernst, Ulrike Schleicher   +31 more
core   +1 more source

Generation of a neonatal sepsis model in humanized mice

, 2012
Streptococcus agalactiae (group B streptococcus (GBS)) is a gram-positive bacterium and a harmless commensal in the gastrointestinal and vaginal flora of healthy adults.
Ernst, Wolfgang
core   +1 more source

Humanized mouse models for inherited thrombocytopenia studies

Platelets, 2023
Inherited thrombocytopenia (IT) is a group of hereditary disorders characterized by a reduced platelet count as the main clinical manifestation, and often with abnormal platelet function, which can subsequently lead to impaired hemostasis.
Xiaojie Wang, Maoshan Chen, Lanyue Hu, Chengning Tan, Xiaoliang Li, Peipei Xue, Yangzhou Jiang, Peipei Bao, Teng Yu, Fengjie Li, Yanni Xiao, Qian Ran, Zhongjun Li, Li Chen   +13 more
doaj   +1 more source

In vivo imaging enables high resolution preclinical trials on patients' leukemia cells growing in mice. [PDF]

, 2012
Xenograft mouse models represent helpful tools for preclinical studies on human tumors. For modeling the complexity of the human disease, primary tumor cells are by far superior to established cell lines.
zur Stadt, Udo, Groiss, Volker, Schneider, Katja, Renier J Brentjens, Nadia Terziyska, Harald Ehrhardt, Jeremias, I., Brentjens, Renier J., Farkasova, K., Katja Schneider, Volker Groiss (106787), Katarina Farkasova (106794), Ehrhardt, Harald, Wagner, E., Renier J. Brentjens (106801), Quintanilla-Martinez, Leticia, Martin Horstmann (45040), Ehrhardt, H., Ernst Wagner (60760), Wagner, Ernst, Leticia Quintanilla-Martinez (33277), Terziyska, N., Katja Schneider (106791), Horstmann, M., Brentjens, R.J., Catarina Castro Alves, Quintanilla-Martinez, L., Zur Stadt, U., Horstmann, Martin, Schneider, K., Ogris, M., Manfred Ogris, Alves, C.C., Nadia Terziyska (106777), Terziyska, Nadia, Jeremias, Irmela, Groiss, V., Irmela Jeremias (106806), Volker Groiss, Udo zur Stadt, Martin Horstmann, Farkasova, Katarina, Ernst Wagner, Irmela Jeremias, Ogris, Manfred, Udo zur Stadt (106803), Catarina Castro Alves (106783), Manfred Ogris (60759), Castro Alves, Catarina, Katarina Farkasova, Leticia Quintanilla-Martinez, Harald Ehrhardt (106798)   +51 more
core   +1 more source

Perspectives on Non-BLT Humanized Mouse Models for Studying HIV Pathogenesis and Therapy

Viruses, 2021
A variety of humanized mice, which are reconstituted only with human hematopoietic stem cells (HSC) or with fetal thymus and HSCs, have been developed and widely utilized as in vivo animal models of HIV-1 infection.
Kazutaka Terahara, Ryutaro Iwabuchi, Yasuko Tsunetsugu-Yokota   +2 more
doaj   +1 more source

Generation of HIV latency in humanized BLT mice

, 2012
Here we demonstrate that a combination of tenofovir, emtricitabine, and raltegravir effectively suppresses peripheral and systemic HIV replication in humanized BLT mice.
Rae Ann Spagnuolo, Krisko, John F, Denton, Paul W, Chateau, Morgan, Paul W. Denton, Shailesh K. Choudhary, Nochi, Tomonori, Archin, Nancy M, Chateau, M., Spagnuolo, R. A., Michael D. Swanson, Tomonori Nochi, Archin, N. M., Swanson, M. D., Swanson, Michael D, Garcia, J. V., Wahl, Angela, Choudhary, S. K., Spagnuolo, Rae Ann, Krisko, J. F., Nochi, T., Rikke Olesen, Morgan Chateau, John F. Krisko, David M. Margolis, Margolis, D. M., Olesen, R., Wahl, A., Choudhary, Shailesh K, Nancy M. Archin, J. Victor Garcia, Denton, P. W., Olesen, Rikke, Garcia, J Victor, Margolis, David M, Angela Wahl   +35 more
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Antibody Production and Diversification in Humanized Mice

, 2023
Many scientists are skeptical of using humanized mice to study the human adaptive immune response. The reasoning behind this skepticism stems from discrepancies in various studies seen previously. A study conducted by Traggiai et al.
Berges, Dr. Brad, Nielsen, Stanton
core  

Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission [PDF]

, 2012
Background: Recently, a number of antibodies capable of broadly neutralizing HIV have been isolated from HIV infected patients, stimulating efforts to develop vaccines capable of eliciting their production in naive individuals.
AB Balazs, Hong, C., Chen, J., S Ouyang, D An, Ouyang, S., An, D., C Hong, D Baltimore, J Chen, Baltimore, D., Balazs, A. B.   +11 more
core   +1 more source

Of Mice and Humans [PDF]

Science, 2011
The technological advances catalyzed by the sequencing of the human genome have been highly beneficial to stem cell research.
openaire   +1 more source