Results 21 to 30 of about 75,155 (200)

Monopoiesis in humans and mice [PDF]

International Immunology, 2018
AbstractMonocytes are a widely conserved cell population in vertebrates with important roles in both inflammation and homeostasis. Under both settings, monocytes continuously arise from hematopoietic progenitors in the bone marrow and, on demand, migrate into tissues through the bloodstream.
Kawamura, Shunsuke, Ohteki, Toshiaki
openaire   +4 more sources

Humanized mice generated by intra-bone marrow injection of CD133-positive hematopoietic stem cells: application to HIV-1 research

Frontiers in Virology, 2023
Animal models are essential for basic and clinical research on virus diseases. Humanized mice (mice reconstituted with human hematopoietic cells) have been effectively used for various virus studies as small animal models.
Takaaki Koma, Tokifumi Odaka, Sung-Il Lee, Naoya Doi, Tomoyuki Kondo, Kazu Okuma, Jun-Ichi Fujisawa, Akio Adachi, Akio Adachi, Masako Nomaguchi   +9 more
doaj   +1 more source

Humanizing Thrombi in Mice [PDF]

Trends in Cardiovascular Medicine, 2011
Antiplatelet therapies form the cornerstone of atherothrombosis prevention, reducing the morbidity and mortality associated with cardiovascular disease. Despite these benefits, there is still an unmet need for more effective and safer pharmacological agents.
Jorge, Magallon, Matthew, Egalka, Thomas G, Diacovo   +2 more
openaire   +2 more sources

Accumulation of Linoleic Acid by Altered Peroxisome Proliferator-Activated Receptor-α Signaling Is Associated with Age-Dependent Hepatocarcinogenesis in Ppara Transgenic Mice

Metabolites, 2023
Long-term ligand activation of PPARα in mice causes hepatocarcinogenesis through a mechanism that requires functional PPARα. However, hepatocarcinogenesis is diminished in both Ppara-null and PPARA-humanized mice, yet both lines develop age-related liver
Xiaoyang Zhu, Qing Liu, Andrew D. Patterson, Arun K. Sharma, Shantu G. Amin, Samuel M. Cohen, Frank J. Gonzalez, Jeffrey M. Peters   +7 more
doaj   +1 more source

Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease

Heliyon, 2021
Background: Chronic graft versus host disease (GVHD) has been reported in humanized mice after the implantation of human hematopoietic stem cells (hu-HSC).
Hiroshi Tsuzuki, Yasuko Nagatsuka, Mitsuhiro Iwata, Noboru Kitamura, Yosuke Nagasawa, Taro Matsumoto, Ryoji Ito, Takeshi Takahashi, Mamoru Ito, Hideki Nakamura, Masami Takei   +10 more
doaj   +1 more source

Characterization of genetic humanized mice with transgenic HLA DP401 or DRA but deficient in endogenous murine MHC class II genes upon Staphylococcus aureus pneumonia

Animal Models and Experimental Medicine, 2023
Background Staphylococcus aureus can cause serious infections by secreting many superantigen exotoxins in “carrier” or “pathogenic” states. HLA DQ and HLA DR humanized mice have been used as a small animal model to study the role of two molecules during ...
Feng Li, Bowen Niu, Lingling Liu, Mengmin Zhu, Hua Yang, Boyin Qin, Xiuhua Peng, Lixiang Chen, Chunhua Xu, Xiaohui Zhou   +9 more
doaj   +1 more source

Human HLA prolongs the host inflammatory response in Streptococcus suis serotype 2 infection compared to mouse H2 molecules

Frontiers in Cellular and Infection Microbiology, 2023
Streptococcus suis (S. suis) is widely acknowledged as a significant zoonotic pathogen in Southeast Asia and China, which has led to a substantial number of fatalities in both swine and humans.
Chengpei Ni, Yi Han, Yajing Wang, Ting Ma, Dan Sha, Yanan Xu, Wenting Cao, Song Gao, Song Gao   +8 more
doaj   +1 more source

Development of Humanized Mouse Models for Infectious Diseases and Cancer

, 2020
While the traditional animal models contributed immensely to biomedical research there remain many knowledge gaps in translating the results from these to humans. In this context, humanized mice transplanted with functional human cells in a physiological

core   +2 more sources

Circadian Photoentrainment in Mice and Humans [PDF]

Biology, 2020
Light around twilight provides the primary entrainment signal for circadian rhythms. Here we review the mechanisms and responses of the mouse and human circadian systems to light. Both utilize a network of photosensitive retinal ganglion cells (pRGCs) expressing the photopigment melanopsin (OPN4).
Russell G. Foster, Steven Hughes, Stuart N. Peirson   +2 more
openaire   +3 more sources

Human delta like 1-expressing human mesenchymal stromal cells promote human T cell development and antigen-specific response in humanized NOD/SCID/IL-2R $$\upgamma $$ γ null (NSG) mice

Scientific Reports, 2021
Human delta-like 1 (hDlk1) is known to be able to regulate cell fate decisions during hematopoiesis. Mesenchymal stromal cells (MSCs) are known to exhibit potent immunomodulatory roles in a variety of diseases.
Do Hee Kwon, Jae Berm Park, Joo Sang Lee, Sung Joo Kim, Bongkum Choi, Ki-Young Lee   +5 more
doaj   +1 more source