Results 1 to 10 of about 75,155 (200)
Protocol to construct humanized mice with adult CD34+ hematopoietic stem and progenitor cells
STAR ProtocolsSummary: Humanized mice, defined as mice with human immune systems, have become an emerging model to study human hematopoiesis, infectious disease, and cancer.
Chun I. Yu +4 more
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Humanized hemato-lymphoid system mice [PDF]
Haematologica, 2016 Over the last decades, incrementally improved xenograft mouse models, supporting the engraftment and development of a human hemato-lymphoid system, have been developed and now represent an important research tool in the field.
Alexandre P.A. Theocharides +4 more
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HIV Replication in Humanized IL-3/GM-CSF-Transgenic NOG Mice
Pathogens, 2019 The development of mouse models that mimic the kinetics of Human Immunodeficiency Virus (HIV) infection is critical for the understanding of the pathogenesis of disease and for the design of novel therapeutic strategies. Here, we describe the dynamics of
Federico Perdomo-Celis +4 more
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A novel clinically relevant human fecal microbial transplantation model in humanized mice
Microbiology SpectrumThe intact immune system of mice exhibits resistance to colonization by exogenous microorganisms, but the gut microbiota profiles of the humanized mice and the patterns of human fecal microbiota colonization remain unexplored.
Shuai Yang +8 more
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Selective expansion of myeloid and NK cells in humanized mice yields human-like vaccine responses
Nature Communications, 2018 Humanized mice are an enabling technology to explore human immunity and disease. Here, Douam et al. provide an in-depth comparison of immune responses to yellow fever vaccine in human vaccinees, conventional and second-generation humanized mice and ...
Florian Douam +11 more
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Patient-Derived Xenograft Models of Breast Cancer and Their Application
Cells, 2019 Recently, patient-derived xenograft (PDX) models of many types of tumors including breast cancer have emerged as a powerful tool for predicting drug efficacy and for understanding tumor characteristics.
Takahiko Murayama, Noriko Gotoh
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Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition.
PLoS ONE, 2017 Since dietary polyphenols can have beneficial effects in prevention and treatment of cancer, we tested the hypothesis that breast cancer patients' intestinal microbiota is modulated by genistein (GE), an isoflavone found in soy, and that microbial ...
Bidisha Paul +8 more
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PLoS Medicine, 2008 BackgroundWorldwide, vaginal transmission now accounts for more than half of newly acquired HIV-1 infections. Despite the urgency to develop and implement novel approaches capable of preventing HIV transmission, this process has been hindered by the lack
Paul W Denton +9 more
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Tracking Human Immunodeficiency Virus-1 Infection in the Humanized DRAG Mouse Model
Frontiers in Immunology, 2017 Humanized mice are emerging as an alternative model system to well-established non-human primate (NHP) models for studying human immunodeficiency virus (HIV)-1 biology and pathogenesis.
Jiae Kim +11 more
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Humanized Mouse Models of Epstein-Barr Virus Infection and Associated Diseases
Pathogens, 2013 Epstein-Barr virus (EBV) is a ubiquitous herpesvirus infecting more than 90% of the adult population of the world. EBV is associated with a variety of diseases including infectious mononucleosis, lymphoproliferative diseases, malignancies such as Burkitt
Ken-Ichi Imadome +2 more
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