Results 11 to 20 of about 75,155 (200)
Innovations, challenges, and minimal information for standardization of humanized mice
EMBO Molecular Medicine, 2020 Mice xenotransplanted with human cells and/or expressing human gene products (also known as “humanized mice”) recapitulate the human evolutionary specialization and diversity of genotypic and phenotypic traits. These models can provide a relevant in vivo
Renata Stripecke +2 more
exaly +6 more sources
Next-generation humanized NSG-SGM3 mice are highly susceptible to Staphylococcus aureus infection [PDF]
Frontiers in Immunology, 2023 Humanized hemato-lymphoid system mice, or humanized mice, emerged in recent years as a promising model to study the course of infection of human-adapted or human-specific pathogens. Though Staphylococcus aureus infects and colonizes a variety of species,
Eslam S Ibrahim +2 more
exaly +5 more sources
A DNA Vaccine Protects Human Immune Cells against Zika Virus Infection in Humanized Mice
EBioMedicine, 2017 A DNA vaccine encoding prM and E protein has been shown to induce protection against Zika virus (ZIKV) infection in mice and monkeys. However, its effectiveness in humans remains undefined.
Guohua Yi, Xuequn Xu, Sojan Abraham
exaly +4 more sources
Advancement of humanized mice and leading applications in immunological disease models [PDF]
Inflammation and RegenerationDisease models are used to evaluate drug candidates, and compounds that are highly effective in vivo models have traditionally been prioritized for development.
Satoru Munakata +5 more
doaj +2 more sources
Potential Pitfalls of the Humanized Mice in Modeling Sepsis
International Journal of Inflammation, 2018 Humanized mice are a state-of-the-art tool used to study several diseases, helping to close the gap between mice and human immunology. This review focuses on the potential obstacles in the analysis of immune system performance between humans and ...
Krzysztof Laudanski +5 more
doaj +2 more sources
Humanized mice: are we there yet? [PDF]
The Journal of Experimental Medicine, 2005 Animal models have been instrumental in increasing the understanding of human physiology, particularly immunity. However, these animal models have been limited by practical considerations and genetic diversity.
Shultz, L D +7 more
core +2 more sources
Frontiers in Immunology, 2021 Mice reconstituted with a human immune system (humanized mice) provide a robust model to study human immunology, vaccinology, and human infectious diseases. However, the development and function of B cells in humanized mice is impaired.
Liang Cheng +17 more
doaj +1 more source
The development and improvement of immunodeficient mice and humanized immune system mouse models
Frontiers in Immunology, 2022 Animal models play an indispensable role in the study of human diseases. However, animal models of different diseases do not fully mimic the complex internal environment of humans.
Jiaxuan Chen +10 more
doaj +1 more source
Current Diabetes Reports, 2012 The genomes of many species have now been completely sequenced including human and mouse. Great progress has been made in understanding the complex genetics that underlie diabetes and obesity in human populations. One of the current challenges is the functional identification and characterization of the genes within loci that are being mapped.
McMurray, Fiona +2 more
openaire +2 more sources
Current Advances in Humanized Mouse Models for Studying NK Cells and HIV Infection
Microorganisms, 2023 Human immunodeficiency virus (HIV) has infected millions of people worldwide and continues to be a major global health problem. Scientists required a small animal model to study HIV pathogenesis and immune responses.
Jocelyn T. Kim +2 more
doaj +1 more source