Results 1 to 10 of about 68,397 (297)

Humanized c-Myc mouse. [PDF]

PLoS ONE, 2012
BACKGROUND: A given tumor is usually dependent on the oncogene that is activated in the respective tumor entity. This phenomenon called oncogene addiction provides the rationale for attempts to target oncogene products in a therapeutic manner, be it by ...
Frank M Lehmann, Samantha Feicht, Florian Helm, Anna Maurberger, Camilla Ladinig, Ursula Zimber-Strobl, Ralf Kühn, Josef Mautner, Armin Gerbitz, Georg W Bornkamm   +9 more
doaj   +8 more sources

Humanized mouse models in MDS [PDF]

Cell Death and Disease
Myelodysplastic syndromes (MDS) are heterogeneous hematopoietic stem cell disorders defined by ineffective hematopoiesis, multilineage dysplasia, and risk of progression to acute myeloid leukemia. Improvements have been made to identify recurrent genetic
Raluca Munteanu, Diana Gulei, Cristian Silviu Moldovan, Emanuele Azzoni, Laura Belver, Richard Feder, Simina Pirv, Anca Dana Buzoianu, Hermann Einsele, Moshe Mittelman, Gabriel Ghiaur, Robert Hasserjian, Ciprian Tomuleasa   +12 more
doaj   +4 more sources

Tocilizumab but not Siltuximab prevents systemic inflammation in a humanized mouse model [PDF]

Frontiers in Immunology
ObjectivesThe present study aimed to assess the therapeutic efficacy of neutralizing monoclonal antibodies targeting a prominent proinflammatory cytokine in a PBMC transfer-induced humanized mouse model of systemic inflammation.MethodsInflammatory ...
Liang Zhang, Liang Zhang, Jacqueline Wax, Jacqueline Wax, Torsten Goldmann, Torsten Goldmann, Afsaneh Mehrpouyan, Afsaneh Mehrpouyan, Antje Müller, Frank Petersen, Frank Petersen, Gabriela Riemekasten, Xinhua Yu, Xinhua Yu   +13 more
doaj   +2 more sources

The development and improvement of immunodeficient mice and humanized immune system mouse models

Frontiers in Immunology, 2022
Animal models play an indispensable role in the study of human diseases. However, animal models of different diseases do not fully mimic the complex internal environment of humans.
Shuzhen Liao, Lawei Yang, Chen Jiaxuan   +2 more
exaly   +3 more sources

Perspectives on Non-BLT Humanized Mouse Models for Studying HIV Pathogenesis and Therapy

Viruses, 2021
A variety of humanized mice, which are reconstituted only with human hematopoietic stem cells (HSC) or with fetal thymus and HSCs, have been developed and widely utilized as in vivo animal models of HIV-1 infection.
Kazutaka Terahara, Ryutaro Iwabuchi, Yasuko Tsunetsugu-Yokota   +2 more
doaj   +2 more sources

Characterization of a humanized mouse model of Charcot-Marie-Tooth type 1A for the discovery of human PMP22-targeting drugs [PDF]

Frontiers in Neurology
Background and aimsCharcot–Marie-Tooth type 1A (CMT1A) is the most common inherited demyelinating peripheral neuropathy caused by duplication of the peripheral myelin protein 22 (PMP22) gene.
Atsuki Taruta, Shin-ichi Matsumoto, Yasushi Masuda, Tetsuaki Hiyoshi, Akina Harada, Yohei Kosugi, Masato Nakashima   +6 more
doaj   +2 more sources

CD133 mRNA-Loaded Dendritic Cell Vaccination Abrogates Glioma Stem Cell Propagation in Humanized Glioblastoma Mouse Model

Molecular Therapy - Oncolytics, 2020
Cancer stem cells are initiating cells of cancer and propagate its growth through self-renewal and differentiation of its daughter cells. CD133 is a cell surface antigen that is present on glioma stem cells and has been used to prospectively isolate ...
Mariza De Peralta-Venturina, John S Yu
exaly   +3 more sources

Humanized Mouse Models of Rheumatoid Arthritis for Studies on Immunopathogenesis and Preclinical Testing of Cell-Based Therapies

Frontiers in Immunology, 2019
Rodent models of rheumatoid arthritis (RA) have been used over decades to study the immunopathogenesis of the disease and to explore intervention strategies.
Katina Schinnerling, CARLOS Rosas, Lilian Soto   +2 more
exaly   +3 more sources

Clinical translation of TLR agonist-modified silicified cancer cell therapy supported by humanized mouse models [PDF]

Molecular Therapy: Oncology
Humanized patient-derived xenograft (huPDX) mouse models are crucial for evaluating the clinical translation of new immune therapeutics. Silicification of cancer cells renders the cells non-viable with enhanced stability and silica surface ...
Mara P. Steinkamp, Danielle Burke, Madigan Morrison, Irina Lagutina, Lillian Fitzpatrick, Rita E. Serda   +5 more
doaj   +2 more sources

Establishment and Phenotypic Analysis of the Novel Gaucher Disease Mouse Model With the Partially Humanized Gba1 Gene and F213I Mutation

Frontiers in Genetics, 2022
Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the GBA1 gene, which produces the glucocerebrosidase (GCase) protein. There are more than 500 mutations reported in GBA1, among which L444P (p.Leu444Pro) and
Jia-ni Guo, Jia-ni Guo, Ming Guan, Nan Jiang, Na Li, Ya-jun Li, Jin Zhang, Duan Ma, Duan Ma   +8 more
doaj   +1 more source