Results 21 to 30 of about 68,397 (297)
Serial Transfer of Human Hematopoietic and Hepatic Stem/progenitor Cells
Bio-Protocol, 2013 A range of assays have been developed to determine the stemness or stem cell activity of human stem cells. The key assays of stem cells are functional: they must show self-renewal and the ability to generate the appropriate tissue.
Qingfeng Chen, Jianzhu Chen
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Comparative transcriptomics in human and mouse [PDF]
Nature Reviews Genetics, 2017 Cross-species comparisons of genomes, transcriptomes and gene regulation are now feasible at unprecedented resolution and throughput, enabling the comparison of human and mouse biology at the molecular level. Insights have been gained into the degree of conservation between human and mouse at the level of not only gene expression but also epigenetics ...
Alessandra, Breschi +2 more
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Complete functional rescue of the ABCA1−/− mouse by human BAC transgenesis
Journal of Lipid Research, 2005 Humanized mouse models are useful tools to explore the functional and regulatory differences between human and murine orthologous genes. We have combined a bioinformatics approach and an in vivo approach to assess the functional and regulatory ...
Jonathan M. Coutinho +11 more
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Humanized Mouse Models of Bacterial Infections. [PDF]
Antibiotics (Basel)Bacterial infections continue to represent a significant healthcare burden worldwide, causing considerable mortality and morbidity every year. The emergence of multidrug-resistant bacterial strains continues to rise, posing serious risks to controlling ...
McDonald K +2 more
europepmc +2 more sources
Development of a humanized mouse model (iPDX).
, 2022 Schematic showing the workflow and the time frame of humanized Pancreatic and Colorectal cancer iPDX mouse model establishment and analysis of T cell engraftment. (PDF)
Harinarayanan Janakiraman (13775369) +4 more
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PLoS ONE, 2021 In organ transplantation, human leukocyte antigen (HLA)-mismatch grafts not only induce the activation of cellular mediated immune response but also the development of chronic antibody-mediated rejection due to the donor-specific anti-HLA antibody (DSA ...
Senichiro Yanagawa +7 more
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Retrovirology, 2020 The development of safe and effective combination antiretroviral therapies for human immunodeficiency virus (HIV) infection over the past several decades has significantly reduced HIV-associated morbidity and mortality. Additionally, antiretroviral drugs
Yash Agarwal +6 more
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A Mouse Model for Human Norovirus [PDF]
mBio, 2013 ABSTRACT Human noroviruses (HuNoVs) cause significant morbidity and mortality worldwide. However, despite substantial efforts, a small-animal model for HuNoV has not been described to date. Since “humanized” mice have been successfully used to study human-tropic pathogens in the past, we challenged BALB/c mice deficient in ...
Taube, Stefan +8 more
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Clitoral development in the mouse and human [PDF]
Differentiation, 2020 The goal of this report is (a) to provide the first detailed description of mouse clitoral development, and (b) to compare mouse and human clitoral development. For this purpose, external genitalia of female mice were examined by wholemount microscopy, histology and immunohistochemistry from 14 days of gestation to 10 days postnatal.
Cunha, Gerald R +4 more
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Development of an Inflammatory CD14+ Dendritic Cell Subset in Humanized Mice
Frontiers in Immunology, 2021 Humanized mouse models are attractive experimental models for analyzing the development and functions of human dendritic cells (DCs) in vivo. Although various types of DC subsets, including DC type 3 (DC3s), have been identified in humans, it remains ...
Ryutaro Iwabuchi +15 more
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