Results 11 to 20 of about 68,397 (297)

A Humanized Mouse Model Generated Using Surplus Neonatal Tissue

Stem Cell Reports, 2018
Summary: Here, we describe the NeoThy humanized mouse model created using non-fetal human tissue sources, cryopreserved neonatal thymus and umbilical cord blood hematopoietic stem cells (HSCs).
Matthew E. Brown, Ying Zhou, Brian E. McIntosh, Ian G. Norman, Hannah E. Lou, Mitch Biermann, Jeremy A. Sullivan, Timothy J. Kamp, James A. Thomson, Petros V. Anagnostopoulos, William J. Burlingham   +10 more
doaj   +2 more sources

A humanized orthotopic mouse model for preclinical evaluation of immunotherapy in Ewing sarcoma [PDF]

Frontiers in Immunology, 2023
The advent of novel cancer immunotherapy approaches is revolutionizing the treatment for cancer. Current small animal models for most cancers are syngeneic or genetically engineered mouse models or xenograft models based on immunodeficient mouse strains.
Wen Luo, Wen Luo, Hai Hoang, Yanling Liao, Jian Pan, Janet Ayello, Mitchell S. Cairo, Mitchell S. Cairo, Mitchell S. Cairo, Mitchell S. Cairo   +9 more
doaj   +3 more sources

A Humanized Mouse Model of Tuberculosis [PDF]

PLoS ONE, 2013
Mycobacterium tuberculosis (M.tb) is the second leading infectious cause of death worldwide and the primary cause of death in people living with HIV/AIDS. There are several excellent animal models employed to study tuberculosis (TB), but many have limitations for reproducing human pathology and none are amenable to the direct study of HIV/M.tb co ...
Veronica E Calderon, Gustavo Valbuena, Yenny Goez, Barbara M Judy, Matthew B Huante, Putri Sutjita, R Katie Johnston, D Mark Estes, Robert L Hunter, Jeffrey K Actor, Jeffrey D Cirillo, Janice J Endsley   +11 more
openaire   +5 more sources

Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models [PDF]

iScience, 2021
Summary: Amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD) is a fatal neurodegenerative disorder, and continued innovation is needed for improved understanding and for developing therapeutics.
Anny Devoy, Georgia Price, Francesca De Giorgio, Rosie Bunton-Stasyshyn, David Thompson, Samanta Gasco, Alasdair Allan, Gemma F. Codner, Remya R. Nair, Charlotte Tibbit, Ross McLeod, Zeinab Ali, Judith Noda, Alessandro Marrero-Gagliardi, José M. Brito-Armas, Muhammet M. Öztürk, Michelle Simon, Edward O'Neill, Sam Bryce-Smith, Jackie Harrison, Gemma Atkins, Silvia Corrochano, Michelle Stewart, Lydia Teboul, Abraham Acevedo-Arozena, Elizabeth M.C. Fisher, Thomas J. Cunningham   +26 more
doaj   +2 more sources

Evaluation of Four Humanized NOD-Derived Mouse Models for Dengue Virus-2 Infection

Pathogens
Dengue is a significant public health problem with no specific viral treatment. One of the main challenges in studying dengue is the lack of adequate animal models recapitulating human immune responses.
Hernando Gutierrez-Barbosa, Sandra Medina-Moreno, Federico Perdomo-Celis, Harry Davis, Joel V. Chua, Juan C. Zapata   +5 more
doaj   +2 more sources

A high-affinity CDR-grafted antibody against influenza A H5N1 viruses recognizes a conserved epitope of H5 hemagglutinin. [PDF]

PLoS ONE, 2014
Highly pathogenic avian influenza (HPAI) H5N1 virus infection is still a potential threat to public health worldwide. While vaccines and antiviral drugs are currently under development, neutralizing antibodies could offer an alternative strategy to ...
Feifei Xiong, Liliang Xia, Jingfang Wang, Biao Wu, Dengyu Wang, Longfang Yuan, Yating Cheng, Hongying Zhu, Xiaoyan Che, Qinghua Zhang, Guoping Zhao, Ying Wang   +11 more
doaj   +1 more source

VraSR Regulatory System Contributes to the Virulence of Community-Associated Methicillin-Resistant Staphylococcus aureus (CA-MRSA) in a 3D-Skin Model and Skin Infection of Humanized Mouse Model

Biomedicines, 2021
The vancomycin-resistance associated sensor/regulator, VraSR two-component regulatory-system (VraSR), regulates virulence and the response of Staphylococcus aureus (SA) to environmental stress.
Nilakshi Barua, Ying Yang, Lin Huang, Margaret Ip   +3 more
doaj   +1 more source

From mouse to human

eLife, 2023
A deep analysis of multiple genomic datasets reveals which genetic pathways associated with atherosclerosis and coronary artery disease are shared between mice and humans.
openaire   +3 more sources

Construction of stable mouse artificial chromosome from native mouse chromosome 10 for generation of transchromosomic mice

Scientific Reports, 2021
Mammalian artificial chromosomes derived from native chromosomes have been applied to biomedical research and development by generating cell sources and transchromosomic (Tc) animals.
Satoshi Abe, Kazuhisa Honma, Akane Okada, Kanako Kazuki, Hiroshi Tanaka, Takeshi Endo, Kayoko Morimoto, Takashi Moriwaki, Shusei Hamamichi, Yuji Nakayama, Teruhiko Suzuki, Shoko Takehara, Mitsuo Oshimura, Yasuhiro Kazuki   +13 more
doaj   +1 more source

Isolation of CD34+ Cells from Human Fetal Liver and Cord Blood

Bio-Protocol, 2013
CD34 is a glycosylated cell surface protein and represents a well-known marker for primitive progenitor cells in various organs, especially cord blood, bone marrow and fetal liver. CD34+ progenitor cells are suitable for a series of studies, e.g.
Qingfeng Chen, Jianzhu Chen
doaj   +1 more source