Results 31 to 40 of about 68,397 (297)

Mouse Model for Human Vitiligo [PDF]

Current Protocols in Immunology, 2018
AbstractVitiligo is an autoimmune skin disease in which the pigment‐producing melanocytes are destroyed by autoreactive CD8+ T cells. As a result, patients develop disfiguring white spots on the skin. This article discusses the first mouse model of vitiligo that develops epidermal depigmentation, similar to disease in human patients.
Rebecca L, Riding, Jillian M, Richmond, John E, Harris   +2 more
openaire   +2 more sources

Activation of human complement by mouse and mouse/human chimeric monoclonal antibodies

Clinical and Experimental Immunology, 1993
SUMMARYThe complement (C)-activating capabilities in human serum of 32 mouse and 10 mouse/human chimeric MoAbs of different isotypes, and their fragments, were tested in vitro. Activation of C via the classical pathway (CP) was performed in 1% factor D-deficient serum in gelatin containing Veronal buffer in the presence of calcium and magnesium (GVB++),
J, Seino, P, Eveleigh, S, Warnaar, L J, van Haarlem, L A, van Es, M R, Daha   +5 more
openaire   +3 more sources

Humanized mouse models for inherited thrombocytopenia studies

, 2023
Inherited thrombocytopenia (IT) is a group of hereditary disorders characterized by a reduced platelet count as the main clinical manifestation, and often with abnormal platelet function, which can subsequently lead to impaired hemostasis.
Fengjie Li, Yanni Xiao, Zhongjun Li, Chengning Tan, Peipei Bao, Maoshan Chen, Teng Yu, Xiaoliang Li, Peipei Xue, Yangzhou Jiang, Xiaojie Wang, Lanyue Hu, Qian Ran, Li Chen   +13 more
core   +1 more source

Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease

Heliyon, 2021
Background: Chronic graft versus host disease (GVHD) has been reported in humanized mice after the implantation of human hematopoietic stem cells (hu-HSC).
Hiroshi Tsuzuki, Yasuko Nagatsuka, Mitsuhiro Iwata, Noboru Kitamura, Yosuke Nagasawa, Taro Matsumoto, Ryoji Ito, Takeshi Takahashi, Mamoru Ito, Hideki Nakamura, Masami Takei   +10 more
doaj   +1 more source

Generation of a neonatal sepsis model in humanized mice

, 2012
Streptococcus agalactiae (group B streptococcus (GBS)) is a gram-positive bacterium and a harmless commensal in the gastrointestinal and vaginal flora of healthy adults.
Ernst, Wolfgang
core   +1 more source

Comparing mouse and human brains

eLife, 2023
Inhibitory circuit motifs in the mouse brain and the human brain are strikingly similar.
Hovy Ho-Wai Wong, Christina You Chien Chou, Alanna Jean Watt, Per Jesper Sjöström   +3 more
openaire   +3 more sources

Leishmania major Infection in Humanized Mice Induces Systemic Infection and Provokes a Nonprotective Human Immune Response

, 2012
Background: Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis.
Uwe Ritter (130470), Schmid, Maximilian, Hanses Frank, Ulrike Schleicher (104689), Frank Hanses, Maximilian Schmid, Florian, Christian, Frank Hanses (148604), Zimara Nicole, Wolfgang Ernst (13060), Wege, Anja Kathrin, Anja Kathrin Wege, Anja Kathrin Wege (148586), Christian Florian, Ernst, Wolfgang, Uwe Ritter, Hanses, Frank, Maximilian Schmid (148609), Florian Christian, Ritter Uwe, Nicole Zimara (148595), Zimara, Nicole, Christian Florian (148590), Schleicher, Ulrike, Ritter, Uwe, Nicole Zimara, Ernst Wolfgang, Schmid Maximilian, Schleicher Ulrike, Wege Anja Kathrin, Wolfgang Ernst, Ulrike Schleicher   +31 more
core   +1 more source

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology [PDF]

, 2017
Cytochrome P450, family 3, subfamily A (CYP3A) enzymes metabolize approximately 50% of commercially available drugs. Recently, we developed fully humanized transchromosomic (Tc) CYP3A mice with the CYP3A cluster including CYP3A4, CYP3A5, CYP3A7, and ...
Asami Oji, Masahito Ikawa, Takashi Yamamoto, Kazuhisa Honma, Kazuomi Nakamura, Shoko Takehara, Mitsuo Oshimura, Azusa Okada, Yasuko Tsukazaki, Kan Chiba, Yasuhiro Kazuki, Satoshi Abe, Naoto Senda, Tetsushi Sakuma, Kanako Kazuki, Kaoru Kobayashi   +15 more
core   +2 more sources

Detection of human immune cells in the humanized mouse. Biomedicine

, 2022
S.37-40Animal models are a useful tool to study pathomechanisms and therapeutic targets in biomedical research. In the last decade the investigation of different humanized mouse models became important in research.
Köberle, M., Lange, F., Rodewohl, A., Scholbach, J.   +3 more
core   +1 more source

Liver-Humanized NSG-PiZ Mice Support the Study of Chronic Hepatitis B Virus Infection and Antiviral Therapies

Microbiology Spectrum, 2023
Hepatitis B virus (HBV) is a pathogen of major public health importance that is largely incurable once a chronic infection is established. Only humans and great apes are fully permissive to HBV infection, and this species restriction has impacted HBV ...
Rossana Colón-Thillet, Daniel Stone, Michelle A. Loprieno, Lindsay Klouser, Pavitra Roychoudhury, Tracy K. Santo, Hong Xie, Laurence Stensland, Sarah L. Upham, Gregory Pepper, Meei-Li Huang, Martine Aubert, Keith R. Jerome   +12 more
doaj   +1 more source