Results 41 to 50 of about 68,397 (297)
Mouse Models of Human Cancer [PDF]
Cancer Research, 2014 Abstract The Helmholtz Alliance Preclinical Comprehensive Cancer Center (PCCC; www.helmholtz-pccc.de) hosted the “1st International Kloster Seeon Meeting on Mouse Models of Human Cancer” in the Seeon monastery (Germany) from March 8 to 11, 2014.
Barbara C, Böck +3 more
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, 2012 Allogeneic stem cell transplantation (allo-SCT) has become an important treatment modality for patients with high-risk acute myeloid leukemia (AML) and is also under investigation for soft tissue sarcomas.
Wels, Winfried +35 more
core +1 more source
Cancer Immunotherapies and Humanized Mouse Drug Testing Platforms
Translational Oncology, 2019 Cancer immunotherapy is a type of treatment that restores and stimulates human immune system to inhibit cancer growth or eradicate cancer. It serves as one of the latest systemic therapies, which has been approved to treat different types of cancer in ...
Qingfeng Chen +3 more
doaj +1 more source
mAbs, 2020 A major asset of many monoclonal antibody (mAb)-based biologics is their persistence in circulation. The MHC class I family Fc receptor, FCGRT, is primarily responsible for this extended pharmacokinetic behavior.
Benjamin E. Low +4 more
doaj +1 more source
Dog as an Outgroup to Human and Mouse
PLoS Computational Biology, 2007 In a recent contribution to PLoS Computational Biology, Cannarozzi, Schneider, and Gonnet published evidence that rodents form an outgroup to human and dog [1], in disagreement with several recent studies suggesting that the dog is an outgroup to the primate–rodent clade [2,3].
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BMC Genomics, 2018 Background The role of PPARα in gene regulation in mouse liver is well characterized. However, less is known about the role of PPARα in human liver. The aim of the present study was to better characterize the impact of PPARα activation on gene regulation
Montserrat A. de la Rosa Rodriguez +5 more
doaj +1 more source
The pluripotent state in mouse and human [PDF]
Development, 2015 In the mouse, naïve pluripotent stem cells (PSCs) are thought to represent the cell culture equivalent of the late epiblast in the pre-implantation embryo, with which they share a unique defining set of features. Recent studies have focused on the identification and propagation of a similar cell state in human.
Davidson, Kathryn C. +2 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Gene Therapy Strategies for HIV/AIDS: Preclinical Modeling in Humanized Mice
Viruses, 2013 In the absence of an effective vaccine and lack of a complete cure, gene therapy approaches to control HIV infection offer feasible alternatives.
Michael S. Bennett, Ramesh Akkina
doaj +1 more source