Results 51 to 60 of about 68,397 (297)
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Interferon-alpha treatment rapidly clears Hepatitis E virus infection in humanized mice
Scientific Reports, 2017 Antiviral treatment options for chronic Hepatitis E Virus (HEV) infections are limited and immunological determinants of viral persistence remain largely unexplored.
Martijn D. B. van de Garde +7 more
doaj +1 more source
Mouse Models for Human Herpesviruses
Pathogens, 2023 More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investigate the consequences of infections and identify novel treatment options, in vivo models are of ...
Ivana Kutle, Anne Dittrich, Dagmar Wirth
openaire +3 more sources
, 2012 Summary of sequence reads generated for each humanized mouse (HuMs), pooled humanized mouse immature B cells (HuMs-ImmB), and human peripheral blood B cell samples (HuPBC).
George Georgiou (167924) +10 more
core +1 more source
Mechanoluminescent HOF Nanotransducers Enabled Sono‐Optogenetics in Parkinsonian Rats
Advanced Functional Materials, EarlyView.We present a mechanoluminescent system utilizing porous hydrogen‐bonded organic frameworks (HOFs) as a toolkit for focused ultrasound‐triggered, non‐invasive light delivery to the deep brain in rats. This approach enables the specific activation of PV‐GPe neurons in dopamine‐depleted Parkinson's disease rat models, resulting in a comparable alleviation
Wenliang Wang +18 more
wiley +1 more source
, 2015 Autoimmune hepatitis (AIH) in humans is a severe inflammatory liver disease characterized by interface hepatitis, the presence of circulating autoantibodies, and hyper‐gammaglobulinemia.
Lapierre, P. +14 more
core +1 more source
HIV Replication in Humanized IL-3/GM-CSF-Transgenic NOG Mice
Pathogens, 2019 The development of mouse models that mimic the kinetics of Human Immunodeficiency Virus (HIV) infection is critical for the understanding of the pathogenesis of disease and for the design of novel therapeutic strategies. Here, we describe the dynamics of
Federico Perdomo-Celis +4 more
doaj +1 more source
Advanced Science, EarlyView.We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang +10 more
wiley +1 more source
Frontiers in Microbiology, 2013 Live attenuated measles virus (MV) has long been recognized as a safe and effective vaccine, and it has served as the basis for development of various MV-based vaccines. However, because MV is a human-tropic virus, the evaluation of MV-based vaccines has
Shota eIkeno +15 more
doaj +1 more source
Scientific Reports, 2022 Humanized liver rodent models, in which the host liver parenchyma is repopulated by human hepatocytes, have been increasingly used for drug development and disease research.
Marisa Carbonaro +17 more
doaj +1 more source