Results 71 to 80 of about 75,155 (200)
Translating Treg Therapy in Humanized Mice [PDF]
, 2015 Regulatory T cells (Treg) control immune cell function as well as non-immunological processes. Their far-reaching regulatory activities suggest their functional manipulation as a means to sustainably and causally intervene with the course of diseases ...
Trinschek, Bettina +11 more
core +1 more source
Onco-Hu™ Models: Humanized NSG™ and NSG™-SGM3 Mice for Immuno-Oncology
, 2016 Understanding the interactions between human immune cells and tumors is paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.
Clinical and Research Services, JAX Mice,
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Colesevelam Reduces Ethanol-Induced Liver Steatosis in Humanized Gnotobiotic Mice
, 2021 Alcohol-related liver disease is associated with intestinal dysbiosis. Functional changes in the microbiota affect bile acid metabolism and result in elevated serum bile acids in patients with alcohol-related liver disease.
Yi Duan +6 more
core +1 more source
Humanized Mice for Brain Infection of Emerging Viruses
, 2021 Studies on the pathogenesis of emerging viruses that present a global threat are critical for pathogen classification and therapeutic development. Humanized mice enable investigation of viral pathogens, including Human immunodeficiency virus (HIV-1 ...
Makarov, Edward
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HIV-1 Elimination in Humanized Mice
, 2019 Human immunodeficiency virus type one (HIV-1) exclusively infects humans and chimpanzees. Therefore, animal models are required for all investigations of viral pathogenesis, therapy and cure.
Su, Hang
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Humanized NSG mice are more susceptible to PVL-induced dermonecrosis.
, 2015 PMN were isolated from the blood of human volunteers and bone marrow of humanized mice or BALB/c mice. (A) Percentage of human CD66B+ and murine Ly6G + cells in the PMN preparations (n = 4). (B) Percentage of hC5aR+ cells in the PMN preparations (n = 4).
Xuemo Fan (281703) +11 more
core +1 more source
Influences of Miltefosine treatment in infected humanized mice.
, 2012 Footpad swelling (A), weight change (B), and parasitic infestation in different organs normalized to human β-actin (D) in L. major (3×106 L. major) infected humanized mice with (n = 6) and without Miltefosine (n = 6) treatment.
Uwe Ritter (130470) +7 more
core +1 more source
Genetic Engineering of Humanized Telomere Mice
Telomere shortening is a hallmark of human aging, and telomerase regulation plays a critical role in cellular proliferation and replicative senescence. In human cells, telomere length imposes a limit on proliferative potential, a phenomenon known as the ...
Kenneth Porter +4 more
core +1 more source
Recent Advances in Allergy Research Using Humanized Mice
, 2019 The prevalence rates of allergic diseases are increasing worldwide, particularly in industrial countries. To date, many mouse models have been generated for allergy research; studies conducted using these models have suggested the importance of cross ...
Yasuhiro Gon +7 more
core +1 more source
Frontiers in NeurologyBackground and aimsCharcot–Marie-Tooth type 1A (CMT1A) is the most common inherited demyelinating peripheral neuropathy caused by duplication of the peripheral myelin protein 22 (PMP22) gene.
Atsuki Taruta +6 more
doaj +1 more source