Results 101 to 110 of about 68,397 (297)

Various types of humanized mouse tumor models [PDF]

There are various novel approaches to cancer immunotherapy. These potential treatments for malignant cancers include the adoptive transfer of natural killer cells, T cell receptor T cells, chimeric antigen receptor T cells, and many more. It is important
Kim, Tae Rang
core  

B/ordering and healthcare access for migrants with precarious status: The role of healthcare workers in counteracting restrictive policies

American Journal of Community Psychology, EarlyView.
Abstract In Canada, precarious migration is largely invisibilized. Nonetheless, b/ordering greatly affects people's realities by limiting access to social rights. In Quebec, migrants with precarious status (MPS) do not have access to healthcare, although Quebec has a “universal” healthcare coverage.
Émilie Pigeon‐Gagné, Jill Hanley, Élise Bourgeois‐Guérin, Pénélope Boudreault   +3 more
wiley   +1 more source

Testing the capacity of humanized immune system mice to induce a protective antibody response against the Lyme disease pathogen

Microbiology Spectrum
Mus musculus has been a key animal model whereby important discoveries on bacterial pathogenesis of the Lyme disease (LD) pathogen, Borreliella burgdorferi (Bb), were made.
Natanel Neumann, Moriah L. Jacobson, Michael A. Brehm, Keith A. Daniels, Jamie Kady, Carey L. O'Donnel, Yuliya Rogovska, Sichao Wang, Artem S. Rogovskyy   +8 more
doaj   +1 more source

The Use of the Humanized Mouse Model in Gene Therapy and Immunotherapy for HIV and Cancer

Frontiers in Immunology, 2018
HIV and cancer remain prevailing sources of morbidity and mortality worldwide. There are current efforts to discover novel therapeutic strategies for the treatment or cure of these diseases.
Mayra A. Carrillo, Anjie Zhen, Scott G. Kitchen   +2 more
doaj   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Generation of a functional humanized Delta-like ligand 4 transgenic mouse model

, 2017
Humanized mouse models are important tools in many areas of biological drug development including, within oncology research, the development of antagonistic antibodies that have the potential to block tumor growth by controlling vascularization and are ...
Morehouse, C., Brohawn, P., Nicholas Holoweckyj, Strout, P., Holoweckyj, N., Kerstin Magnell, Pilataxi, F., Johansson, J., Johan Johansson, Chris Morehouse, Magnell, K., Pernilla Gregersson, Wiseman, J., Gregersson, Pernilla,, Cho, S., John Wiseman, Philip Brohawn, Song Cho, Patrick Strout, Fernanda Pilataxi   +19 more
core   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

Mouse Models of Hepatitis B Virus Infection Comprising Host-Virus Immunologic Interactions

Pathogens, 2014
Hepatitis B virus (HBV) infection is one of the most prevalent infectious diseases associated with various human liver diseases, including acute, fulminant and chronic hepatitis; liver cirrhosis; and hepatocellular carcinoma.
Tadashi Inuzuka, Ken Takahashi, Tsutomu Chiba, Hiroyuki Marusawa   +3 more
doaj   +1 more source

Estimated parameters for HBV infection in humanized mouse.

Estimated parameters for HBV infection in humanized mouse.
Lena Allweiss (366520), Yasuhito Tanaka (39138), Naotoshi Nakamura (12083048), Shinji Nakaoka (3326025), Maura Dandri (560334), Kwang Su Kim (1960972), Yasuhisa Fujita (10344689), Koichi Watashi (222543), Hyeongki Park (15990598), Masashi Iwamoto (1399939), Kosaku Kitagawa (9187891), Shingo Iwami (266092), Kazuyuki Aihara (44090), Alan S. Perelson (7832039), Takara Nishiyama (18137383), Sanae Hayashi (18137380)   +15 more
core   +1 more source

A humanized microbiota mouse model of ovalbumin-induced lung inflammation

, 2016
There is increasing evidence for a role of early life gut microbiota in later development of asthma in children. In our recent study, children with reduced abundance of the bacterial genera Lachnospira, Veillonella, Faecalibacterium, and Rothia had an ...
Finlay, BB, Dean, J, Brown, EM, Turvey, SE, Finlay, B. Brett, Arrieta, M-C, Arrieta, Marie-Claire, Chan, ES, Chan, Edmond S., Brown, Eric M., Russell, Shannon L., Dean, John, Russell, SL, Sadarangani, M, Nimmo, M, Sadarangani, Manish, Nimmo, Michael, Turvey, Stuart E.   +17 more
core   +1 more source