Results 131 to 140 of about 68,397 (297)

Humanized chimeric mouse models of hepatitis B virus infection

, 2017
Hepatitis B virus (HBV) infection is associated with an increased risk of hepatic cirrhosis, hepatocellular carcinoma, fulminant hepatitis and end-stage hepatic failure. Despite the availability of anti-HBV therapies, HBV infection remains a major global
Jun Li, Suwan Sun
core   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

Autoreactivity vs autoimmunity: characteristics of autoantigen‐specific CD4 T‐cells in rheumatoid arthritis and health.

Arthritis &Rheumatology, Accepted Article.
Background CD4 T cells specific for citrullinated (cit)‐peptides are key players in RA immunopathogenesis. Characterising these cells and identifying features of healthy and RA‐associated autoreactivity will provide valuable insight into disease mechanisms and form the basis of immune state biomarkers to facilitate the next generation of RA treatments.
James A. Stanway, Daniel Peters, Helen Waller, Jeremy Lakey, Henrique De Paula Lemos, Kristian Williams, Abbie Degnan, Julie Diboll, Abdul Mannan Baru, David Tough, Arthur G. Pratt, Catharien M.U. Hilkens, Amy E. Anderson, John D. Isaacs   +13 more
wiley   +1 more source

Humanized Mouse Models as An Experimental Tool to Investigate Disease Immunology

, 2017
Many studies of human immunology have been limited to ex vivo analysis due to ethical considerations. Detailed study, however, requires in vivo analysis, as ex vivo analysis of human immune cells does not always represent in vivo status. Therefore, small
Takashi Onoe
core   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

A more human mouse [PDF]

Nature Immunology, 2018
openaire   +2 more sources

A humanized mouse model for adeno-associated viral gene therapy

Clinical translation of AAV-mediated gene therapy requires preclinical development across different experimental models, often confounded by variable transduction efficiency.
Seh Hoon Oh, Thao N. Galvan, Sarah E. Woodfield, Trevor J. Gonzalez, Helen L. Streff, Alan Rosales, Sanjeev A. Vasudevan, Charles A. Gersbach, Mercedes Barzi, Tong Chen, Francis P. Pankowicz, John Goss, Yunhan Ma, Aravind Asokan, Karl-Dimiter Bissig, Anna Mae Diehl, Sabrina Collias, Beatrice Bissig-Choisat   +17 more
core   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

, 2005
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse ...
Feigenbaum, Lionel, Chen, Hua-Tang, Galina V. Petukhova, Sharan, Shyam, Lionel Feigenbaum, R. Daniel Camerini-Otero, Nussenzweig, André, Celeste, Arkady, Kruhlak, Michael, Yong-Ping Yang, Difilippantonio, Simone, Camerini-Otero, R. Daniel, Martin, Bernardo Reina San, Arkady Celeste, André Nussenzweig, Petukhova, Galina V., Yang, Yong-Ping, Eckhaus, Michael, Manova, Katia, Bernardo Reina San Martin, Francois Van Laethem, Michel Nussenzweig, Simone Difilippantonio, Michael Eckhaus, Fernandez-Capetillo, Oscar, Michael Kruhlak, Nussenzweig, Michel, Shyam Sharan, Laethem, Francois Van, Oscar Fernandez-Capetillo, Hua-Tang Chen, Katia Manova   +31 more
core   +1 more source

Carrier‐free self‐assembled nanomedicine for combination‐therapy of acute myeloid leukemia

BMEMat, EarlyView.
CPDS combines drugs with three different mechanisms of action to achieve a multi‐mechanism combination therapy for AML by directly killing tumor cells and activating anti‐tumor immunity. Abstract As the main acute myeloid leukemia (AML) clinical treatment, the chemotherapy alone cannot meet the clinical therapeutic needs due to the high heterogeneity ...
Meihong Chai, Rui Zhang, Haiyin Yang, Jiyue Xing, Tianyuan Hu, Mengxi Zhu, Rui Li, Xiaoli Chen, Beibei Zhao, Yang Lan, Stefan Barth, Yuanyu Huang, Li Zhang, Mengjie Zhang, Huining He   +14 more
wiley   +1 more source