Results 201 to 210 of about 68,397 (297)

Establishment of a humanized mouse model of pulmonary fibrosis for advancing drug validation strategies. [PDF]

Sci Rep
Hasan MN, Chae Y, Lee SY, Kang YM.
europepmc   +1 more source

Safe to Speak, Teach, and Research? Experiences of Reprisals in Danish Academia

The British Journal of Sociology, EarlyView.
Liv Bjerre, Adam Rasmus Jensen, Steen Nepper Larsen, Frederik Boris Hylstrup Olsen, Jes Søe Pedersen, Mikkel Thorup, Maria Toft   +6 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Characterization of a humanized mouse model of Duchenne muscular dystrophy to support the development of genetic medicines. [PDF]

Dis Model Mech
Braunreiter K, Kempton A, Mejia-Guerra MK, Murray A, Baine S, Adegboye K, Haile A, Kumar Ahuja SJ, Fedoce A, Liu C, Burch P, Kabadi AM.   +11 more
europepmc   +1 more source

CKLF‐like MARVEL transmembrane domain‐containing superfamily 8 (CMTM8) promotes Notch signalling to maintain CD8+ T cell‐ and NK cell‐dependent tumour immune escape

British Journal of Pharmacology, EarlyView.
Background and Purpose The CKLF‐like MARVEL transmembrane domain containing superfamily (CMTM) has an important role in tumour immunity. The role of CMTM8 in tumour immune microenvironment (TIME) remains unknown. The aim was to investigate the relationship between CMTM8 and antitumour immunity. Experimental Approach Lentiviral system was established to
Fanglin Li, Longhua Gu, Runqiu Chen, Zhiying Li, Rong Zhang, Chen Chen, Yi Liu, Xinhang Zheng, Yiting Wang, Shanna Wu, Jianhua Sun, Jing Chen, Bingshun Wang, Likun Gong, Yiru Long   +14 more
wiley   +1 more source

A Lung-Immune Dual-Humanized Mouse Using Cryopreserved Tissue Enables Infection and Immune Profiling of Human Common Cold Coronaviruses. [PDF]

Adv Sci (Weinh)
Cheng C, Sun J, Lu C, Yu Q, He Y, Wu B, Ren D, Ding S, Zhao J, Li Y.   +9 more
europepmc   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, EarlyView.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source

Distinct human small intestinal microbiome communities underlie visceral hypersensitivity in a humanized mouse model. [PDF]

J Clin Invest
Comba IY, Louwies T, Mars RA, Xiao Y, Sekhon PK, Edwards BS, Willits A, Shields-Cutler RR, Bellampalli S, Mercado-Perez A, Tienter DR, Till LM, Linden DR, Farrugia G, Beyder A, Smith-Edwards KM, Kashyap PC.   +16 more
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source