Results 231 to 240 of about 68,397 (297)

Therapeutic effects of hypoimmunogenic universal human iPSC-derived endothelial cells in a humanized mouse model of peripheral artery disease. [PDF]

Stem Cell Res Ther
Choi J, Kim NG, Kong D, Kim MJ, Kang BC, Kwon D, Kim DH, Kang KS.   +7 more
europepmc   +1 more source

Development of Chimeric Antigen Receptor‐Modified NK Cells for the Immunotherapy of Adult T‐Cell Leukemia/Lymphoma

European Journal of Haematology, EarlyView.
ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive hematological malignancy with a poor prognosis and limited therapeutic options. ATL cells exhibit aberrant surface glycosylation patterns resulting from dysregulated glycosyltransferase expression, representing a potentially tumor‐specific therapeutic target.
Yuichiro Uchida, Seigo Tateo, Masahiro Wakao, Hiroyuki Shinchi, Hayate Sawayama, Akira Fukumoto, Makoto Yoshimitsu, Yasuo Suda   +7 more
wiley   +1 more source

Post‐Transplant Bendamustine as a Platform for Immune Modulation After Allogeneic Hematopoietic Cell Transplantation

European Journal of Haematology, EarlyView.
ABSTRACT Post‐transplant cyclophosphamide (PT‐CY) remains the standard of care for graft‐versus‐host disease (GvHD) prophylaxis in haploidentical hematopoietic cell transplantation (HCT), yet relapse, delayed immune reconstitution, infections, and organ toxicity represent persistent and clinically meaningful limitations.
Megan J. Cracchiolo, Richard J. Simpson, Emmanuel Katsanis   +2 more
wiley   +1 more source

Modulation of Human Immune Cells by Propyl-Propane Thiosulfonate (PTSO) Inhibits Colorectal Tumor Progression in a Humanized Mouse Model. [PDF]

Nutrients
Rodríguez-Sojo MJ, Gbati L, Molina-Tijeras JA, Ho-Plágaro A, Vezza T, López-Escánez L, Griñán-Lisón C, Marchal JA, Baños A, Rodríguez-Sánchez MJ, García-García J, Ruiz-Malagón AJ, Gálvez J, Rodríguez-Cabezas ME, Rodríguez-Nogales A.   +14 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

A rescue fanconi anemia humanized mouse model with endogenous FA mutation and high human hematopoietic stem cell chimerism. [PDF]

Mol Ther Methods Clin Dev
Choo S, Tong AH, Fields E, Mack HM, Humbert O, Radtke S, Kiem HP.   +6 more
europepmc   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, EarlyView.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Transplantation of human kidney organoids elicited a robust allogeneic response in a humanized mouse model. [PDF]

Kidney Int
Mon-Wei Yu S, Choi JY, Kady J, De Cos M, Wong JS, King E, Younis N, Al Rahy N, Al Chaar S, Djebli H, Eskandari S, Samuel S, Merhej T, Sukumar N, Lin JR, Chen JY, Xu Y, Santagata S, Weins A, Yeung M, Cravedi P, Campbell KN, Lemos D, Bonventre JV, Brehm MA, Azzi J.   +25 more
europepmc   +1 more source

Mitochondrial transfer in acute myeloid leukaemia and multiple myeloma: Mechanisms, consequences and potential therapeutic opportunities

The FEBS Journal, EarlyView.
Mitochondria can be transferred from bone marrow cells to cancer cells in acute myeloid leukaemia and multiple myeloma, boosting tumour energy production, growth, and drug resistance. This review highlights key transfer mechanisms and shows how targeting mitochondrial movement and dynamics may offer new therapeutic strategies to limit cancer ...
Ebubechukwu Nwarunma, Mark T. S. Williams   +1 more
wiley   +1 more source

Humanized mouse model reveals T cell ANXA2 as a potential therapeutic target in ischemic stroke. [PDF]

iScience
Zhang T, Zheng X, Lu A, Li S, Li K, Huang X, Liu Y, Chen W, Huang S, He N, Tsang CK, Mai H, Xu A, Lu D.   +13 more
europepmc   +1 more source