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Identification of human and mouse chromosomes in human-mouse hybrids by centromere fluorescence
Experimental Cell Research, 1974Abstract Differences between the centromeric regions of mouse and human chromosomes have been revealed with a staining technique which is based on the quenching by 5-bromodeoxyuridine of the fluorescence of the dye 33258 Hoechst. The differences can be used to distinguish between human and mouse chromosomes in human-mouse hybrids.
M S, Lin, S A, Latt, R L, Davidson
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Mouse-Human Somatic Cell Hybrids: Loss of Mouse and Human Chromosomes
Somatic Cell and Molecular Genetics, 1998Testicular germ cell tumors are unusual because they can be cured in over 80% of patients with combination chemotherapy. In order to identify chromosomes carrying genes controlling drug sensitivity, fusions were made between a mouse embryonal carcinoma (EC) cell line, F9, and a human bladder cancer cell line, MGH-UI.
X, Wang, M, Fox, S, Povey, J R, Masters
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HUMAN CYP2D6 AND MOUSE CYP2DS: ORGAN DISTRIBUTION IN A HUMANIZED MOUSE MODEL
Drug Metabolism and Disposition, 2005Polymorphic cytochrome P450 (P450) 2D6 (CYP2D6) metabolizes several classes of therapeutic drugs, endogenous neurochemicals, and toxins. A CYP2D6-humanized transgenic mouse line was previously developed to model CYP2D6-poor and -extensive metabolizer phenotypes. Human CYP2D6 was detected in the liver, kidney, and intestine of these animals.
Sharon L, Miksys +3 more
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Expression of the human cytomegalovirus genome in mouse cells and in human-mouse heterokaryons
Archives of Virology, 1977Mouse cells with an established human cytomegalovirus (HCMV) infection were fused with susceptible human embryonic fibroblast cells. CMV-specific early antigens could be demonstrated in the cytoplasm and cell-membrane of the heterokaryons. Treatment with 5-iodo-2'-deoxyuridine (IUdR) of the heterokaryons or of the latently infected mouse cells, prior ...
I, Boldogh +3 more
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The synthesis and actions of mouse and human interferons in mouse-human hybrid cells
Virology, 1978Abstract Lines of mouse-human hybrid cells segregating either mouse or human chromosomes were used for the analysis of various aspects of the production and actions of mouse and human interferons. In one of the hybrid cell lines capable of producing both mouse and human interferons, the proportion of the two interferon activities produced varied ...
Frankfort, H M +3 more
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Expression of mouse and human fibronectin in mouse-human somatic cell hybrids
Experimental Cell Research, 1979Abstract Using antisera to the human and mouse fibronectin (Large External Transformation Sensitive (LETS) protein), we studied the expression of mouse and human fibronectin in mouse-human somatic cell hybrids segregating either human or mouse chromosomes.
L, Zardi, B, Carnemolla, C M, Croce
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Chimeric human and mouse spheroids
Virchows Archiv B Cell Pathology Including Molecular Pathology, 1993We investigated structures resembling embryoid bodies (EBs), grown intraperitoneally in nude mice after the injection of xenografted human teratocarcinoma cells. Following in situ hybridization of paraffin sections containing these EB-like structures with either human or mouse total genomic DNA, two species-specific types of cell nuclei were localized.
Walt H, Emmerich P
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A smarter mouse with human astrocytes
BioEssays, 2013What is the biological basis for human cognition? Our understanding why human brains make us smarter than other animals is still in its infancy. In recent years, astrocytes have been shown to be indispensable for neuronal survival, growth, synapse formation, and synapse function.
Ye, Zhang, Ben A, Barres
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Comparison of Human and Mouse Pseudogenes
2007 IEEE Symposium on Computational Intelligence and Bioinformatics and Computational Biology, 2007Pseudogenes are formed by either gene duplication or retro transposition and yet unknown to express any RNA or produce any protein, which may be due to some defects in their structure. Because of the non-functional nature, pseudogenes are considered important resources in the study of evolutionary history and phylogenetic comparison of genomes ...
Pooja, Jagath C. Rajapakse
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Recapitulating human cancer in a mouse
Nature Biotechnology, 2013A panel of experts discusses the challenge of translating findings from current mouse models to the clinic.
Lynda, Chin +5 more
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