Results 71 to 80 of about 10,847,213 (333)

Olfactory Orientation and Navigation in Humans. [PDF]

, 2015
Although predicted by theory, there is no direct evidence that an animal can define an arbitrary location in space as a coordinate location on an odor grid. Here we show that humans can do so. Using a spatial match-to-sample procedure, humans were led to
Arter, Jennifer, Cook, Amy, JACOBS, Lucia F., Sulloway, Frank   +3 more
core   +4 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Humans--a threat to humanity.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 2008
Humanity is but a blip on the time-scale of life on earth. But that blip is all that we have, and our present global course guarantees its extinction. What are the realities? Why should the situation be of interest to medical practitioners and what should we be doing?
openaire   +4 more sources

Rethinking Representation: the Challenge of Non-humans [PDF]

, 2014
This article argues that the standard model of political representation mischaracterises the structure of representation. After surveying the classical types of representation and their application to non-humans, the basic nature of representation is ...
Tanasescu, Mihnea
core   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Human arm redundancy: a new approach for the inverse kinematics problem

Royal Society Open Science
The inverse kinematics (IK) problem addresses how both humans and robotic systems coordinate movement to resolve redundancy, as in the case of arm reaching where more degrees of freedom are available at the joint versus hand level.
Avi Barliya, Nili Krausz, Hila Naaman, Enrico Chiovetto, Martin Giese, Tamar Flash   +5 more
doaj   +1 more source

Would humans without language be apes? [PDF]

, 2003
The bedrock of comparative psychology of cognition, especially where nonhuman primates are concerned, rests on Darwin's famous account according to which continuity would be the main trait leading from the animal to the human mind.
Vauclair, J
core  

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

Sketch-a-Net that Beats Humans

, 2015
We propose a multi-scale multi-channel deep neural network framework that, for the first time, yields sketch recognition performance surpassing that of humans.
Hospedales, Timothy, Song, Yi-Zhe, Xiang, Tao, Yang, Yongxin, Yu, Qian   +4 more
core   +1 more source