Results 101 to 110 of about 228,754 (301)

Engraftment of sheep splenic lymphocytes into NBSGW mice and application in Brucella infection

open access: yesAnimal Models and Experimental Medicine, EarlyView.
A sheep splenocyte‐reconstituted mouse model (Sh‐Spl mice) was established via intravenous injection of sheep splenic lymphocytes into immunodeficient mice to evaluate Brucella infection. Abstract Background The development of immune reconstituted xenograft mouse models has addressed the limitations imposed by interspecies immunological differences in ...
Xiaowei Wang   +9 more
wiley   +1 more source

Dose‐dependent pathogenicity and inflammatory imbalance in severely immunodeficient mice infected with mpox virus

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This study establishes an NPG (NOD.Cg‐Prkdcscid Il2rgtm1/Vst) mouse model for severe monkeypox virus infection in immunocompromised hosts, demonstrating dose‐dependent disease severity and revealing that unbalanced pro‐inflammatory cytokine release drives pathogenesis, providing insights for therapeutic interventions. Abstract The global spread of mpox
Na Li   +11 more
wiley   +1 more source

The effect of HIV-exposure on immune responses to expanded programme on immunization vaccines and antigens

open access: yes, 2013
Includes abstract.Includes bibliographical references.Immunization against vaccine-preventable infections is essential to reducing childhood morbidity and mortality.
Kidzeru, Elvis Banboye
core  

Immune responses to Fasciola hepatica infection, and Fasciola hepatica derived antigens [PDF]

open access: yes, 2003
The aim of this study was to investigate immune responses as a result of infection with the parasitic helminth, Fasciola hepatica. Analysis of IL-4 and Interferon-y cytokines described a predominant type 2 immune response in BALB/c mice infected with ...
Walshe, Alan
core  

Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing

open access: yes, 1988
Krämer A, Herth D, von Keyserlingk H, et al. Non-responsiveness to hepatitis-B vaccination: revaccination and immunogenetic typing. Klinische Wochenschrift.
Sommer, D.   +7 more
core   +1 more source

Recent advances in the construction of humanized animal models and applications in translational medicine

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Advances in Research on COVID-19 Vaccination for People Living with HIV

open access: yesInfectious Diseases & Immunity, 2022
Junyan Jin   +4 more
doaj   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello   +20 more
wiley   +1 more source

Proinflammatory Epstein–Barr Virus Antibody Functions Track with Disease Activity in Multiple Sclerosis

open access: yesAnnals of Neurology, EarlyView.
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens   +9 more
wiley   +1 more source

Leishmania infantum and dog : immunological and epidemiological studies about infection and disease

open access: yes, 2001
L'objectiu d'aquesta tesi va ser obtenir nous coneixements sobre la immunologia i epidemiologia de la infecció per Leishmania en gossos que viuen en zones endèmiques.
Alberola, Jordi, Solano Gallego, Laia
core  

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