Results 161 to 170 of about 173,621 (252)

Time‐Resolved Multi‐Omics Identify Biomarkers of Immediate Reactions to mRNA Vaccination

Allergy, EarlyView.
We compared early vaccine‐induced immune and metabolic signatures and downstream immunity after second and booster BNT162b2 doses in participants with sARs, ISSRs, or no reactions. Neutrophil mobilization, antiviral programs, and robust anti‐S‐antibody responses occurred across reaction groups.
Ana Olivera, Benjamin Schwarz, Brittany Dulek, Ian S. LaCroix, Min Li, Lindsay Chatman, Muhammad B. Khalid, Ellen Zektser, Karen Laky, Stella Hartono, Eric Bohrnsen, Cole D. Kimzey, Eric Chu, Roa Harb, Pamela A. Frischmeyer‐Guerrerio   +14 more
wiley   +1 more source

Optimizing Humoral Immunity for Durable and Broad Protection in Flavivirus Vaccines. [PDF]

Vaccines (Basel)
Park JY, Lee HM.
europepmc   +1 more source

IgE‐Binding Bacterial Components Not Yet Documented in the Allergen Databases and Their Allergenic Mechanisms: An EAACI Position Paper

Allergy, EarlyView.
ABSTRACT Among bacteria that are associated with the development and/or exacerbation of allergic/atopic diseases, several have been described to produce IgE‐binding components. However, only one bacterial protein, Bac s 1, is currently listed in the official database of the World Health Organization/International Union of Immunological Societies (WHO ...
Uta Jappe, Marua Abu Risha, Ioana Agache, Claus Bachert, Barbara Bröker, Riccardo Castagnoli, Gabriele Gadermaier, Richard E. Goodman, Amir Guemari, Christiane Hilger, Alain Jacquet, Sabine Kespohl, Ludger Klimek, Annette Kuehn, Jonas Lidholm, Vera Mahler, Markus Ollert, Thomas A. Platts‐Mills, Monika Raulf, Peter Schmid‐Grendelmeier, Frieder Schmiedeke, Marianne van Hage, Joana Vitte, Josefina Zakzuk, Anna Pomés   +24 more
wiley   +1 more source

Systematic review and meta-analysis of humoral immunity proteins and mortality in sepsis. [PDF]

Crit Care
Villa A, Dewar F, Pisciotta W, Rai A, Kerneis S, Batum G, McDonnell T, Scully M, McHugh TD, Hilpert K, Gilroy D, de Nooijer A, Netea MG, Hedetoft M, Bermejo-Martin JF, Akatsuka M, Heinz CC, Venet F, Monneret G, Meessen J, Cheng TH, Zhang M, Caironi P, Giamarellos-Bourboulis EJ, de la Torre Terrón MC, Ebelt H, Rademaker E, Bodelsson M, Tverring J, Mi Y, Knight JC, Lindsey ML, Langley RJ, Kingsmore SF, Brealey D, Singer M, Arulkumaran N.   +36 more
europepmc   +1 more source

Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases

Allergy, EarlyView.
ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz, Salvador Iborra, Carlos Blanco, Ruperto González‐Pérez, Emilio Nuñez‐Borque, Can Zeyneloglu, Huseyn Babayev, Ozlem Göksel, Tuncay Göksel, Musa Khaitov, Dmitry Kudlay, Yadong Gao, Mustafa Sevim, Marie‐Charlotte Brüggen, Oral Alpan, Ming Wang, Luo Zhang, María J. Torres, Mohamed Shamji, Mübeccel Akdis, Kari C. Nadeau, Ismail Ogulur, Cezmi A. Akdis   +22 more
wiley   +1 more source

Poly(I:C) and R848 adjuvants elicit sizeable humoral immunity to liver stage malaria antigens. [PDF]

Front Immunol
Tandel N, Thakkar M, Ahuja M, Shah J, Trivedi DD, Pied S, Singh AP, Prajapati C, Tyagi RK, Dalai SK.   +9 more
europepmc   +1 more source

Efficacy and Safety of Abatacept Versus Placebo During Peanut Oral Immunotherapy for Adults With Severe Peanut Allergy

Allergy, EarlyView.
In this Phase 2a trial, severely peanut‐allergic participants were randomized to abatacept versus placebo with peanut oral immunotherapy (OIT) for 24 weeks, followed by 12 weeks of OIT alone. No significant difference was observed for the primary efficacy outcome (the relative change from baseline in peanut‐specific/total IgE ratio at 24 weeks), but ...
Marie‐Lee Simard, Camille Braun, Éloise Antony, Émilie Roy, Marie‐Ève Gingras, François Graham, Anne Des Roches, Louis Paradis, Kathryn Samaan, Florence Gingras‐Lessard, Roxane Labrosse, Thomas Eiwegger, Philippe Bégin   +12 more
wiley   +1 more source

Divergent Cellular and Humoral Immunity to BK Polyomavirus in Healthy Adults and Renal Transplant Recipients Based on Blood and Urine Samples: Implications for Immune-Guided Monitoring. [PDF]

Biomedicines
Fallatah DI, Christmas S.
europepmc   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

microRNA-25 drives immune checkpoint therapy resistance by repressing innate and humoral immunity via Syndecan-3. [PDF]

Nat Commun
Zhu Z, Han W, Deng Y, Jia Z, Baidwan G, Wu L, Jakhmola S, Wang T, Logeswaran D, Wen J, Sun AY, Bray B, Li N, Wang L, Hui H, Wu J, Patel SP, Rana TM.   +17 more
europepmc   +1 more source