Results 171 to 180 of about 173,621 (252)

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Infectious bursal disease virus suppresses humoral immunity via blocking antibody affinity maturation in chickens. [PDF]

iScience
Guo Y, Zhou Z, Jiao H, Gao L, Li X, Cao H, Wang Y, Zheng SJ.   +7 more
europepmc   +1 more source

Temporal trends in infectious risk among multiple myeloma patients treated with daratumumab: A meta‐analysis

British Journal of Haematology, EarlyView.
Summary Anti‐cluster of differentiation 38 (Anti‐CD38) monoclonal antibodies such as daratumumab are widely used in multiple myeloma (MM), yet the timing and magnitude of infectious risk remain incompletely defined. We performed an individual patient‐level meta‐analysis of six randomized trials (N = 2989) comparing daratumumab‐ versus non‐daratumumab ...
Alissa Visram, Hira Mian, James Lee, Aaron Jones, Gregory R. Pond, Doris Hansen, Surbhi Sidana, Luciano J. Costa   +7 more
wiley   +1 more source

Pneumococcal membrane particles promote serotype-independent cellular and humoral immunity and protect against pneumococcal colonization. [PDF]

Proc Natl Acad Sci U S A
Dookie R, Narciso AR, Gaytán MO, Narayana Moorthy A, Chakraborty S, Thorsdottir S, Boss J, Righetti F, Karlsson J, Heurgren M, Normark S, Henriques-Normark B.   +11 more
europepmc   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

NF-κB/RelA signaling required for CD40-induced humoral immunity depends on specific NEMO lysine residues in mice. [PDF]

EMBO J
Li D, Wuerzberger-Davis SM, Chen Y, Phan FP, Yu M, Lisiero DN, Aguilar CC, Cleven T, Tejera MM, Khatri P, Medina N, Chen YC, Wang N, Tsourkas P, Ong I, Bednarski JJ, Dinh HQ, Hoffmann A, Sleckman BP, Suzuki A, Roopra A, Suresh M, Wang D, Miyamoto S.   +23 more
europepmc   +1 more source

The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders

Brain Pathology, EarlyView.
Aquaporin‐4 antibody‐positive neuromyelitis spectrum disorder is characterized by large tissue destructive lesions in medulla, spinal cord, and optic nerves, with only partial recovery from clinical symptoms, and by lesions with very little tissue destruction and mostly complete recovery from clinical symptoms, as seen in the area postrema ...
Qian Yu, Yoshiki Takai, Naoya Yamazaki, Sarah Brandl, Katharina M. Mair, Thibault Bouderlique, Maria Eleni Kastriti, Igor Adameyko, Romana Höftberger, Markus Reindl, Jan Bauer, Monika Bradl   +11 more
wiley   +1 more source

AI-aided design of multi-epitope peptide vaccine elicits cellular and humoral immunity to broad Omicron subvariants. [PDF]

Zool Res
Zhang K, Wang G, Liu T, Li M, Ding L, Zhao Y, Xu J, Li H, Sun J, Zhang X, Chen J, Zhao G, Geng X, Long Y, Gong L.   +14 more
europepmc   +1 more source

Identifying regulatory muscle processes in infantile and adult Pompe patients using a multi‐omic and morphological approach

Brain Pathology, EarlyView.
The study highlights differences in the regulatory processes of skeletal muscle, such as sarcomeric contractility, lysosomal and autophagic function, metabolic activity and immune regulation, at transcriptomic and proteomic levels in infantile and adult Pompe disease.
Alexander Schaiter, Keerthika Lohanadan, Alexander Mensch, Andreas Hentschel, Angela Rosenbohm, Cornelia Kornblum, Angela Roth, Tara Procida‐Kowalski, Heidrun H. Krämer, Andreas Hahn, Jörg Höhfeld, Dieter O. Fürst, Werner Stenzel, Peter F. M. van der Ven, Andreas Roos, Marek Bartkuhn, Anne Schänzer   +16 more
wiley   +1 more source