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Multifunctional tumor vaccines carrying thalidomide regulate T cell exhaustion and ferroptosis for immunotherapy strategies

VIEW, EarlyView.
MTV can greatly achieved antigen presenting cell (APCs), and THA will be released from the polyplex core and enhanced antigen presenting, thereby prompting APC maturation and antigen presenting. The membrane antigens on MTV are degraded into small peptides by proteasomes and presented by MHC complexes.
Anmin Huang +9 more
wiley +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma +6 more
wiley +1 more source

Effects of Bone Morphogenetic Protein‐7 on Steroid‐Induced Extracellular Matrix Accumulation in Human Trabecular Meshwork Cells

FASEB BioAdvances, EarlyView.
Long‐term steroid use can elevate intraocular pressure (IOP) and lead to steroid‐induced glaucoma by promoting extracellular matrix (ECM) accumulation in the trabecular meshwork (TM). This study demonstrates that bone morphogenetic protein‐7 (BMP‐7), delivered via a micellized protein transduction domain (mPTD), effectively inhibits steroid‐induced ECM
Eun Woo Kim +9 more
wiley +1 more source

Lytic Transglycosylase Deficiency Increases Susceptibility to β‐lactam Antibiotics But Reduces Susceptibility to Vancomycin in Escherichia coli

Microbiology and Immunology, EarlyView.
ABSTRACT In Staphylococcus aureus, a gram‐positive pathogen, vancomycin‐resistant strains become susceptible to β‐lactam antibiotics, referred to as the “seesaw effect.” However, in gram‐negative bacteria, the phenomenon is less clear. Here, we analyzed the gene‐knockout effects of eight lytic transglycosylases (slt, mltA, mltB, mltC, mltD, mltE, mltF,
Takahiko Kimura +4 more
wiley +1 more source

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido +4 more
wiley +1 more source

A novel framework to build saliva‐based DNA methylation biomarkers: Quantifying systemic chronic inflammation as a case study

Aging Cell, Volume 24, Issue 4, April 2025.
In this study, we describe a novel multi‐omics framework to train saliva‐based DNA methylation (DNAm) biomarkers that are reproducible and biologically interpretable. By leveraging a reliability dataset with replicates across tissues, we demonstrate knowledge transfer from blood DNAm to saliva DNAm data using DNAm proxies of blood proteins (EpiScores).
Lisa J. Schmunk +34 more
wiley +1 more source

Disease Aggravation With Age in an Experimental Model of Multiple Sclerosis: Role of Immunosenescence

Aging Cell, Volume 24, Issue 5, May 2025.
Age‐related differences in EAE outcomes stem from combined peripheral and CNS factors. Key peripheral adaptive immunity changes include altered naïve/memory T cell ratios, Th1 skewing, increased suppressive Tregs, CD4+ T cell exhaustion, enhanced B cell antigen presentation, and reduced NK cell cytotoxicity.
María Dema +6 more
wiley +1 more source

A Single‐Cell Transcriptome Atlas Characterizes the Immune Landscape of Human Testes During Aging

Aging Cell, EarlyView.
This study utilized single‐cell RNA sequencing to analyze immune cells in 33 human testis samples (ages 21–69). We found age‐related alterations in monocytes and MRC1hi TRM, with shifts in phagocytosis, cytokine, and antigen presentation, contributing to low‐grade inflammation in aging. These findings provide insights into immune aging in human testis.
Qiaoling Jiang +10 more
wiley +1 more source

The 15‐Year Survival Advantage: Immune Resilience as a Salutogenic Force in Healthy Aging

Aging Cell, EarlyView.
Human aging shows puzzling diversity: similar aging rates yet vastly different health outcomes. Our study of ~17,500 people revealed a health‐promoting trait (more common in women) linked to strong immune resilience and high expression of TCF7, a key immune gene. This trait enables individuals to fight infections like COVID‐19 more effectively, respond
Muthu Saravanan Manoharan +176 more
wiley +1 more source

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

Aging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox +13 more
wiley +1 more source