Results 71 to 80 of about 28,868 (258)
Ubiquitin-modifying enzymes in Huntington’s disease
Frontiers in Molecular Biosciences, 2023 Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the N-terminus of the HTT gene. The CAG repeat expansion translates into a polyglutamine expansion in the mutant HTT (mHTT) protein, resulting in intracellular ...
Karen A. Sap +4 more
doaj +1 more source
Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Advanced Therapeutics, EarlyView.This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar +7 more
wiley +1 more source
Neurobiology of Disease, 2001 The cause of Huntington's disease (HD) is a pathological expansion of the polyglutamine domain within the N-terminal region of huntingtin. Neuronal intranuclear inclusions and cytoplasmic aggregates composed of the mutant huntingtin within certain ...
Wanjoo Chun +6 more
doaj
The cryo-electron microscopy structure of huntingtin
Nature, 2018 Huntingtin (HTT) is a large (348 kDa) protein that is essential for embryonic development and is involved in diverse cellular activities such as vesicular transport, endocytosis, autophagy and the regulation of transcription.
Q. Guo +13 more
semanticscholar +1 more source
Huntingtin-lowering strategies for Huntington’s disease
Expert Opinion on Investigational Drugs, 2020 Introduction Huntington’s disease (HD) is an incurable, autosomal dominant neurodegenerative disease caused by an abnormally long polyglutamine tract in the huntingtin protein.
R. Barker +3 more
semanticscholar +1 more source
Probing How Anti‐huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid‐State NMR
Chemistry – A European Journal, EarlyView.Antibodies are widely used to recognize, detect, and target aggregated and misfolded amyloid‐forming proteins, including those associated with HD. Studying such interactions on a structural level is a challenge. Parlato and colleagues report on their use of solid‐state NMR and electron microscopy to probe how such antibodies bind to the fuzzy coat of ...
Raffaella Parlato +3 more
wiley +1 more source
PLoS ONE, 2014 A hallmark of Huntington's disease is the pronounced sensitivity of striatal neurons to polyglutamine-expanded huntingtin expression. Here we show that cultured striatal cells and murine brain striatum have remarkably low levels of phosphorylation of ...
Julia Leitman +6 more
doaj +1 more source
Exploration, EarlyView.Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang +4 more
wiley +1 more source
EMBO Molecular Medicine, 2013 In Huntington disease (HD), polyglutamine expansion in the huntingtin protein causes specific neuronal death. The consequences of the presence of mutant huntingtin in other tissues are less well understood.
Cristovão Moreira Sousa +8 more
doaj +1 more source
Disease Models & Mechanisms, 2022 Circadian disturbances are early features of neurodegenerative diseases, including Huntington's disease (HD). Emerging evidence suggests that circadian decline feeds into neurodegenerative symptoms, exacerbating them.
Pavitra Prakash +2 more
doaj +1 more source