Results 91 to 100 of about 19,992 (185)

High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model.

PLoS ONE, 2011
To identify Huntington's Disease therapeutics, we conducted high-content small molecule and RNAi suppressor screens using a Drosophila primary neural culture Huntingtin model.
Joost Schulte, Katharine J Sepp, Chaohong Wu, Pengyu Hong, J Troy Littleton   +4 more
doaj   +1 more source

Huntingtin [PDF]

Science-Business eXchange, 2008
openaire   +2 more sources

Preserved VPS13A distribution and expression in Huntington’s disease: divergent mechanisms of action for similar movement disorders?

Frontiers in Neuroscience
VPS13A disease and Huntington’s disease (HD) are two basal ganglia disorders that may be difficult to distinguish clinically because they have similar symptoms, neuropathological features, and cellular dysfunctions with selective degeneration of the ...
Esther García-García, Esther García-García, Esther García-García, Maria Carreras-Caballé, Maria Carreras-Caballé, Albert Coll-Manzano, Alba Ramón-Lainez, Alba Ramón-Lainez, Alba Ramón-Lainez, Gisela Besa-Selva, Gisela Besa-Selva, Gisela Besa-Selva, Esther Pérez-Navarro, Esther Pérez-Navarro, Esther Pérez-Navarro, Cristina Malagelada, Cristina Malagelada, Cristina Malagelada, Jordi Alberch, Jordi Alberch, Jordi Alberch, Jordi Alberch, Mercè Masana, Mercè Masana, Mercè Masana, Manuel J. Rodríguez, Manuel J. Rodríguez, Manuel J. Rodríguez   +27 more
doaj   +1 more source

Navigating the neuronal recycling bin: Another look at huntingtin in coordinating autophagy

Autophagy Reports
Neurons, as post–mitotic and long–lived cells, rely heavily on autophagy to maintain cellular homoeostasis and ensure proper function. Huntingtin (HTT), a protein central to Huntington’s disease (HD), has emerged as a putative multifunctional regulator ...
Thomas J. Krzystek, Shermali Gunawardena
doaj   +1 more source

Huntingtin [PDF]

, 2020
openaire   +1 more source

Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1

Advanced Science
Polyglutamine (polyQ) tract length expansion (≥ 36 residues) within the N‐terminal exon‐1 of Huntingtin (Httex1) leads to Huntington's disease, a neurodegenerative condition marked by the presence of intranuclear Htt inclusions.
Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal   +2 more
doaj   +1 more source

Huntingtin and mitosis

Huntingtine et mitose La maladie de Huntington (MH) est une maladie neurodégénérative héréditaire autosomique dominante. Elle résulte d’une expansion anormale de glutamines (polyQ) dans la partie N-terminale de la protéine huntingtine (HTT ; codé par HTT).
openaire   +2 more sources

Untangling huntingtin's mysteries [PDF]

Nature Medicine, 2000
openaire   +2 more sources

Huntingtin [PDF]

, 2019
openaire   +1 more source

Huntingtin (HTT) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources