Results 111 to 120 of about 25,505 (239)
, 2008 N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien +4 more
core
ROS-Specific Huntingtin Interactions: Huntingtin chromatin retention dynamics by FRAP with veliparib
, 2019 <p>Measurement of huntingtin chromatin recruitment dynamics by fluorescence recovery after photobleaching (FRAP) of the YFP-tagged huntingtin-specific intrabody, nucHCB2, under conditions of oxidative stress and PARP inhibition</p>This ...
Maiuri, Tamara +3 more
core +1 more source
NEURAL ROSETTES FORMATION AS A NEWLY EMERGENT HUNTINGTIN FUNCTION [PDF]
, 2010 Huntingtin is a large, ubiquitous, partially unknown protein, in which mutation in its N-terminus is the cause of genetic, neurodegenerative disease called Huntington Disease.
V. LO SARDO
core +1 more source
Exploring and Targeting the Connection of Iron and Copper Homeostasis to Neurodegenerative Diseases
MedComm, Volume 7, Issue 6, June 2026.Iron and copper dyshomeostasis, along with their interactions with key intrinsically disordered proteins (e.g., Aβ, tau, α‐synuclein) have a strong implication in the onset and progression of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), Prion diseases (PrDs), Huntington's disease (HD), Wilson's disease (WD),
Xin Liu +9 more
wiley +1 more source
Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles
MedComm, Volume 7, Issue 6, June 2026.This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang +12 more
wiley +1 more source
Transcriptional Regulation of the Huntingtin Gene
Journal of Huntington's Disease, 2018 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the HTT gene, which encodes for an abnormal polyglutamine tract in the huntingtin protein (HTT). This review examines the known mechanisms of HTT gene regulation.
Thomson, Sarah B., Leavitt, Blair R.
openaire +3 more sources
The huntingtin protein in Huntington disease
, 2017 Huntingtin disease (HD) is an autosomal dominant inheritable disease that mainly affects the brain. HD is caused by expansion of a CAG repeat within exon 1 of the huntingtin gene giving rise to the expression of a mutant huntingtin protein with an ...
Schut, M.H.
core
MedComm, Volume 7, Issue 6, June 2026.This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
, 1996 Huntington's disease (HD) is an inherited neurodegenerative disorder caused by the expansion of a CAG repeat in a gene coding for a protein of unknown function.
Wood, J. D. +4 more
core +1 more source