Results 131 to 140 of about 25,505 (239)
Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease
Neuroprotection, Volume 4, Issue 2, Page 111-130, June 2026.In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong +3 more
wiley +1 more source
Localization and function of the Drosophila huntingtin protein [PDF]
, 2007 Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2007."September 3, 2007."Includes bibliographical references (p. 34-40).Huntington's Disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expansion of a ...
Mediatore, James D
core
, 2016 Conflicting reports exist in the literature regarding the role of wild-type huntingtin in determining the toxicity of the aggregated, mutant huntingtin in Huntington’s disease (HD).
Ankan Kumar Bhadra (144866) +2 more
core +1 more source
Cholesterol Modulates Huntingtin Binding to and Aggregation on Lipid Membranes
, 2015 Huntington disease is an autosomal dominant neurodegenerative disorder. The abnormally long CAG-repeats in the huntingtin gene that encode an expanded polyglutamine stretch which promotes self-assemble of huntingtin into different aggregation species ...
Gao, Xiang
core +1 more source
Aging Cell, Volume 25, Issue 6, June 2026.This study demonstrates that α‐synuclein expression stabilizes the proteasome activator Blm10, thereby linking α‐synuclein stress to changes in proteasome composition. Blm10/PA200‐capped 20S proteasomes efficiently degrade both monomeric and oligomeric α‐synuclein and remain resistant to α‐synuclein‐induced inhibition.
Tariq T. Ali +7 more
wiley +1 more source
The many roles of huntingtin in intracellular trafficking
, 2013 Huntingtin is present at multiple stages of the endocytic and recycling pathway. Huntingtin interacts with many proteins which are involved with clathrin coated pit formation (1) and clathrin mediated endocytosis (2), including the AP-2 complex, syndapin,
Alison Twelvetrees (467856)
core +1 more source
Characterization of the Huntingtin gene promoter and Huntingtin transcriptional regulation
, 2015 Huntington’s disease (HD) is a late onset, neurological, autosomal dominant genetic disorder. Despite being associated to a defined genetic mutation within the huntingtin gene (HTT), little is known about its transcriptional regulation. HTT is expressed, at varying levels, throughout the body.
openaire +1 more source
The FEBS Journal, Volume 293, Issue 11, Page 3376-3398, June 2026.Redox environment modulates in vitro aggregation of Ataxin‐3, the protein implicated in spinocerebellar ataxia type 3. Reducing conditions stabilize native monomers and prevent aggregation, whereas oxidative conditions promote the formation of non‐native conformers and disulfide‐linked oligomers within the Josephin domain (JD).
Martyna Podlasiak +10 more
wiley +1 more source
Expression of Normal and Mutant Huntingtin in the Developing Brain
, 1996 Huntington’s disease (HD) is caused by a genetic mutation that results in a polyglutamine expansion in huntingtin. The time course of neuronal loss in the HD striatum and other affected brain regions before the onset of symptoms is unknown.
Pradeep G. Bhide +10 more
core +1 more source