Results 131 to 140 of about 40,748 (225)
Transcriptional Regulation of the Huntingtin Gene
Journal of Huntington's Disease, 2018 Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide expansion in the HTT gene, which encodes for an abnormal polyglutamine tract in the huntingtin protein (HTT). This review examines the known mechanisms of HTT gene regulation.
Thomson, Sarah B., Leavitt, Blair R.
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Hsc70-induced changes in clathrin-auxilin cage structure suggest a role for clathrin light chains in cage disassembly [PDF]
, 2013 The molecular chaperone, Hsc70, together with its co-factor, auxilin, facilitates the ATP-dependent removal of clathrin during clathrin-mediated endocytosis in cells.
Brodsky, Frances M. +10 more
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Taking a Break From Huntingtin [PDF]
Molecular Therapy - Nucleic Acids, 2012 Three groups have forged an important collaboration to test the utility of antisense oligonucleotides (ASOs) as a therapeutic modality for the treatment of Huntington's disease (HD), a fatal neurodegenerative disease manifesting in ~75,000 individuals in the United States and Europe alone.1 HD is one of a group of dominantly inherited neurodegenerative
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Characterization of the Huntingtin gene promoter and Huntingtin transcriptional regulation
, 2015 Huntington’s disease (HD) is a late onset, neurological, autosomal dominant genetic disorder. Despite being associated to a defined genetic mutation within the huntingtin gene (HTT), little is known about its transcriptional regulation. HTT is expressed, at varying levels, throughout the body.
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Advanced SciencePolyglutamine (polyQ) tract length expansion (≥ 36 residues) within the N‐terminal exon‐1 of Huntingtin (Httex1) leads to Huntington's disease, a neurodegenerative condition marked by the presence of intranuclear Htt inclusions.
Priyesh Mohanty +2 more
doaj +1 more source
Huntingtine et mitose La maladie de Huntington (MH) est une maladie neurodégénérative héréditaire autosomique dominante. Elle résulte d’une expansion anormale de glutamines (polyQ) dans la partie N-terminale de la protéine huntingtine (HTT ; codé par HTT).
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