Results 141 to 150 of about 40,748 (225)

Huntingtin (HTT) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources

Genetic suppressor of autophagy defects in huntingtin null cells identified using a mutagenesis screen in Dictyostelium discoideum. [PDF]

BMC Mol Cell Biol
Cuoco L, Gill SE, Francois L, Souders S, DeMasi C, Moore JR, Chain FJJ.   +6 more
europepmc   +1 more source

Profilin reduces aggregation and phase separation of huntingtin N-terminal fragments by preferentially binding to soluble monomers and oligomers [PDF]

, 2018
Aimin Li, Ammon E. Posey, Kiersten M. Ruff, Marc I. Diamond, Rohit V. Pappu, Scott L. Crick, Tyler S. Harmon   +6 more
core   +2 more sources

Mutant huntingtin expression in somatostatin-positive interneurons contributes to neurophysiological and behavioral phenotypes in BACHD mice. [PDF]

Dis Model Mech
Fowler JA, Scarduzio M, Pool C, Mahan CD, Gray M.   +4 more
europepmc   +1 more source

AMT-130 gene therapy: a promising disease-modifying approach for Huntington's disease. [PDF]

Ann Med Surg (Lond)
Mwape C, Qureshi AA, Saeed MZ, Fatima A, Jamil A, Mahmood H, Batool A, Khan AM.   +7 more
europepmc   +1 more source

Corrigendum: The Generation of Mouse and Human Huntington Disease iPS Cells Suitable for In vitro Studies on Huntingtin Function

Frontiers in Molecular Neuroscience, 2017
Wojciech J. Szlachcic, Kalina Wiatr, Marta Trzeciak, Marek Figlerowicz, Maciej Figiel   +4 more
doaj   +1 more source

Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates. [PDF]

J Biol Chem
Lugo J, Xu H, Chen J, Khoshnan A, Langen R.   +4 more
europepmc   +1 more source

Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin. [PDF]

JCI Insight
Jeong H, Qin Y, Xu F, Trajkovic K, Kim MJ, Marotta N, Hamada K, Allada R, Yang S, Krainc D.   +9 more
europepmc   +1 more source

Perturbation of multiprotein complexes in skeletal muscle induces protective proteases in the CNS that degrade pathogenic proteins. [PDF]

NPJ Aging
Rai M, Baddeley HJE, Chuang CL, Platt A, Curley M, Finkelstein D, Demontis F.   +6 more
europepmc   +1 more source

In Vivo PET Imaging of [¹⁸F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease. [PDF]

J Nucl Med
Zajicek F, Elvas F, Miranda A, Akkermans J, Verhaeghe J, Dominguez C, Doot R, Khetarpal V, Bard J, Liu L, Staelens S, Bertoglio D.   +11 more
europepmc   +1 more source