Results 151 to 160 of about 19,992 (185)
Luteolin and neuroinflammation: a multi-target therapeutic strategy for central nervous system disorders. [PDF]
Front PharmacolHuang J +7 more
europepmc +1 more source
Some of the next articles are maybe not open access.
Related searches:
Related searches:
New England Journal of Medicine, 2012
Huntington's disease was the first disease whose causative gene (HTT) was mapped to a chromosome, and yet almost 30 years later, rational treatments do not exist. A recent study using a mouse model supports a strategy to knock down HTT RNA.
Neil, Aronin, Melissa, Moore
openaire +2 more sources
Huntington's disease was the first disease whose causative gene (HTT) was mapped to a chromosome, and yet almost 30 years later, rational treatments do not exist. A recent study using a mouse model supports a strategy to knock down HTT RNA.
Neil, Aronin, Melissa, Moore
openaire +2 more sources
Calretinin interacts with huntingtin and reduces mutant huntingtin‐caused cytotoxicity
Journal of Neurochemistry, 2012AbstractHuntington's disease (HD) is a devastating neurodegenerative disorder caused by an expansion of CAG trinucleotide repeats encoding for polyglutamine (polyQ) in the huntingtin (Htt) gene. Despite considerable effort, the mechanisms underlying the toxicity of the mutated Htt protein remains largely uncertain. To identify novel therapeutic targets,
Gaofeng, Dong +9 more
openaire +2 more sources
The Huntingtin Transport Complex
BiochemistryA dynamic network of scaffolding molecules, adaptor proteins, and motor proteins work together to orchestrate the movement of proteins, mRNA, and vesicular cargoes. Defects in intracellular transport can often lead to neurodegeneration. Huntingtin (HTT) is a ubiquitously expressed scaffolding protein with a multitude of cellular roles, including ...
Emily N. P. Prowse +3 more
openaire +2 more sources
Science's STKE, 2002
Huntington's disease (HD) is characterized by progressive brain neurodegeneration, often leading to dementia. A mutation in the huntingtin protein and nuclear accumulation of the mutant are associated with the pathology of HD, but it is not yet clear how the mutant protein induces the death of neurons.
openaire +2 more sources
Huntington's disease (HD) is characterized by progressive brain neurodegeneration, often leading to dementia. A mutation in the huntingtin protein and nuclear accumulation of the mutant are associated with the pathology of HD, but it is not yet clear how the mutant protein induces the death of neurons.
openaire +2 more sources
Characterization of neuron-specific huntingtin aggregates in human huntingtin knock-in mice
Neuroscience Research, 2007Huntington's disease (HD) is caused by a mutation causing expanded polyglutamine tracts in the N-terminal fragment of huntingtin. A pathological hallmark of HD is the formation of aggregates in the striatal neurons. Here we report that ageing human huntingtin knock-in mice expressing mutant human huntingtin contained neuronal huntingtin aggregates, as ...
Hirohide, Sawada +8 more
openaire +2 more sources
Mutant HTT (huntingtin) impairs mitophagy in a cellular model of Huntington disease
Autophagy, 2021Marta Martínez-Vicente +2 more
exaly