Results 151 to 160 of about 25,505 (239)

Huntingtin [PDF]

, 2020
openaire   +1 more source

Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington's Disease

, 2019
Huntington's disease is a neurodegenerative disorder caused by a CAG repeat expansion in the first exon of huntingtin gene (HTT) encoding for a toxic polyglutamine protein.
Leumann, Christian, Garcia, Luis, Imbert, Marine, Blandel, Florence, Goyenvalle, Aurelie   +4 more
core   +1 more source

Huntingtin and mitosis

Huntingtine et mitose La maladie de Huntington (MH) est une maladie neurodégénérative héréditaire autosomique dominante. Elle résulte d’une expansion anormale de glutamines (polyQ) dans la partie N-terminale de la protéine huntingtine (HTT ; codé par HTT).
openaire   +2 more sources

Transient Interdomain Interactions Modulate the Monomeric Structural Ensemble and Self‐Assembly of Huntingtin Exon 1

Advanced Science
Polyglutamine (polyQ) tract length expansion (≥ 36 residues) within the N‐terminal exon‐1 of Huntingtin (Httex1) leads to Huntington's disease, a neurodegenerative condition marked by the presence of intranuclear Htt inclusions.
Priyesh Mohanty, Tien Minh Phan, Jeetain Mittal   +2 more
doaj   +1 more source

Untangling huntingtin's mysteries [PDF]

Nature Medicine, 2000
openaire   +2 more sources

Huntingtin [PDF]

, 2019
openaire   +1 more source

Huntingtin (HTT) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources

Inhibition of calcineurin by FK506 protects against polyglutamine-huntingtin toxicity through an increase of huntingtin phosphorylation at S421

Huntington's disease (HD) is caused by an abnormal expanded polyglutamine (polyQ) repeat in the huntingtin protein. Insulin-like growth factor-1 acting through the prosurvival kinase Akt mediates the phosphorylation of huntingtin at S421 and inhibits the
Deglon, N., Colin, E., Aebischer, P., Humbert, S., Saudou, F., Pardo, R., Regulier, E.   +6 more
core   +1 more source

Striatal Neuron Excitability Is Regulated by Huntingtin in the Adult Brain. [PDF]

eNeuro
Barron JC, Greenland ML, Carew SJ, Ashrafganjoie F, Hurley EP, Kennedy CM, Nafar F, Moore CS, Parsons MP.   +8 more
europepmc   +1 more source

Lipid Composition Drives Mutant Huntingtin Dimerization and Membrane Association: Insights from Computational Simulations. [PDF]

Molecules
Nicoara C, Criscuolo E, De Cristofaro A, Fezza F, Maccarrone M.   +4 more
europepmc   +1 more source