Results 171 to 180 of about 25,505 (239)

Perturbation of multiprotein complexes in skeletal muscle induces protective proteases in the CNS that degrade pathogenic proteins. [PDF]

NPJ Aging
Rai M, Baddeley HJE, Chuang CL, Platt A, Curley M, Finkelstein D, Demontis F.   +6 more
europepmc   +1 more source

Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtin. [PDF]

JCI Insight
Jeong H, Qin Y, Xu F, Trajkovic K, Kim MJ, Marotta N, Hamada K, Allada R, Yang S, Krainc D.   +9 more
europepmc   +1 more source

In Vivo PET Imaging of [¹⁸F]CHDI-385, a Radioligand for Mutant Huntingtin Aggregates in a Mouse Model of Huntington Disease. [PDF]

J Nucl Med
Zajicek F, Elvas F, Miranda A, Akkermans J, Verhaeghe J, Dominguez C, Doot R, Khetarpal V, Bard J, Liu L, Staelens S, Bertoglio D.   +11 more
europepmc   +1 more source

SQSTM1/p62 UFMylation Enhances Autophagic Clearance of Pathogenic Mutant Huntingtin. [PDF]

Int J Biol Sci
Wang X, Lv X, Jiang H, Zhu W, Cao L, Zhou L, Lin F, Deng R, Hu LF, Ma J, Li JB, Xu G.   +11 more
europepmc   +1 more source

Huntingtin in the amygdaloid basolateral complex is correlated with Vonsattel staging in Huntington's disease. [PDF]

Brain Commun
Sanchez-Migallon P, Flores-Cuadrado A, Villanueva-Anguita P, Rabano A, Vaamonde J, Saiz-Sanchez D, Mohedano-Moriano A, Astillero-Lopez V, Soriano-Herrador C, Martinez-Marcos A, Ubeda-Banon I.   +10 more
europepmc   +1 more source

Surface-Engineered Precision Nano-Systems for Targeted Treatment of Huntington's Disease: A Review of Recent Advancements. [PDF]

Int J Nanomedicine
Zhang J, Nie L, Ma J, Wang X.
europepmc   +1 more source

Huntingtin polyglutamine expansions misdirect axonal transport by perturbing motor and adaptor recruitment. [PDF]

iScience
Prowse ENP, Turkalj BA, Sébastien M, Gursu L, Beaudet D, Feng J, Zhou C, McBride HM, Brouhard GJ, Pouladi MA, Hendricks AG.   +10 more
europepmc   +1 more source

Metabolic reprogramming is critical to microglial activation in Huntington's disease. [PDF]

JCI Insight
Jauhari A, Monek AC, Abakumova OS, Singh T, Singh S, Wang X, Clise CS, Carlisle DL, Friedlander RM.   +8 more
europepmc   +1 more source

Overview of Huntington's Disease and Emerging Treatment Strategies: A Narrative Review. [PDF]

Cureus
Vega AJ, Hernandez GV, O'Malley PA, Robin CJ, Parra AN, Varrassi G, Shekoohi S, Kaye AD.   +7 more
europepmc   +1 more source

Huntingtin and its allies at the cortico-striatal synapse. [PDF]

Cell Death Dis
Zuccato C, Scolz A, Iennaco R.
europepmc   +1 more source