Results 11 to 20 of about 19,301 (228)

Huntingtin-Associated Protein 1 in Mouse Hypothalamus Stabilizes Glucocorticoid Receptor in Stress Response [PDF]

Frontiers in Cellular Neuroscience, 2020
Huntingtin-associated protein 1 (Hap1) was initially identified as a brain-enriched protein that binds to the Huntington’s disease protein, huntingtin. Unlike huntingtin that is ubiquitously expressed in the brain, Hap1 is enriched in the brain with the ...
Xingxing Chen, Xingxing Chen, Xingxing Chen, Ning Xin, Yongcheng Pan, Yongcheng Pan, Louyin Zhu, Peng Yin, Qiong Liu, Qiong Liu, Weili Yang, Xingshun Xu, Shihua Li, Xiao-Jiang Li   +13 more
doaj   +2 more sources

Detection of alpha-rod protein repeats using a neural network and application to huntingtin.

PLoS Computational Biology, 2009
A growing number of solved protein structures display an elongated structural domain, denoted here as alpha-rod, composed of stacked pairs of anti-parallel alpha-helices.
Gareth A Palidwor, Sergey Shcherbinin, Matthew R Huska, Tamas Rasko, Ulrich Stelzl, Anup Arumughan, Raphaele Foulle, Pablo Porras, Luis Sanchez-Pulido, Erich E Wanker, Miguel A Andrade-Navarro   +10 more
doaj   +2 more sources

Mutant huntingtin protein decreases with CAG repeat expansion: implications for therapeutics and bioassays. [PDF]

Brain Commun
Landles C, Osborne GF, Phillips J, Canibano-Pico M, Nita IM, Ali N, Bobkov K, Greene JR, Sathasivam K, Bates GP.   +9 more
europepmc   +2 more sources

Quantifying Huntingtin Protein in Human Cerebrospinal Fluid Using a Novel Polyglutamine Length-Independent Assay. [PDF]

J Huntingtons Dis, 2022
Fodale V, Pintauro R, Daldin M, Spiezia MC, Macdonald D, Bresciani A.   +5 more
europepmc   +3 more sources

Quantifying mutant huntingtin protein in human cerebrospinal fluid to support the development of huntingtin-lowering therapies. [PDF]

Sci Rep, 2023
AbstractHuntington’s disease (HD) is caused by a cytosine adenine guanine-repeat expansion in the huntingtin gene. This results in the production of toxic mutant huntingtin protein (mHTT), which has an elongated polyglutamine (polyQ) stretch near the protein’s N-terminal end.
Vauleon S, Schutz K, Massonnet B, Gruben N, Manchester M, Buehler A, Schick E, Boak L, Hawellek DJ.   +8 more
europepmc   +4 more sources

Inhibition of mitochondrial protein import by mutant huntingtin [PDF]

Nature Neuroscience, 2014
Mitochondrial dysfunction is associated with neuronal loss in Huntington's disease (HD), a neurodegenerative disease caused by an abnormal polyglutamine expansion in huntingtin (Htt). However, the mechanisms linking mutant Htt and mitochondrial dysfunction in HD remain unknown.
Hiroko Yano, Sergei V. Baranov, Oxana V. Baranova, Jinho Kim, Yanchun Pan, Svitlana Yablonska, Diane L. Carlisle, Robert J. Ferrante, Albert H. Kim, Robert M. Friedlander   +9 more
openalex   +3 more sources

A role of cellular translation regulation associated with toxic Huntingtin protein. [PDF]

Cell Mol Life Sci, 2020
Joag H, Ghatpande V, Desai M, Sarkar M, Raina A, Shinde M, Chitale R, Deo A, Bose T, Majumdar A.   +9 more
europepmc   +3 more sources

The evolution of the huntingtin-associated protein 40 (HAP40) in conjunction with huntingtin [PDF]

BMC Evolutionary Biology, 2020
AbstractBackgroundThe huntingtin-associated protein 40 (HAP40) abundantly interacts with huntingtin (HTT), the protein that is altered in Huntington’s disease (HD). Therefore, we analysed the evolution of HAP40 and its interaction with HTT.ResultsWe found that in amniotes HAP40 is encoded by a single-exon gene, whereas in all other organisms it is ...
Manuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang Baumeister, Qiang Guo, Rubén Fernández-Busnadiego, Andrei N. Lupas, Stefan Kochanek   +8 more
openaire   +8 more sources

Effect of post-mortem delay on N-terminal huntingtin protein fragments in human control and Huntington disease brain lysates. [PDF]

PLoS ONE, 2017
Huntington disease is associated with elongation of a CAG repeat in the HTT gene that results in a mutant huntingtin protein. Several studies have implicated N-terminal huntingtin protein fragments in Huntington disease pathogenesis.
Menno H Schut, Stefano Patassini, Eric H Kim, Jocelyn Bullock, Henry J Waldvogel, Richard L M Faull, Barry A Pepers, Johan T den Dunnen, Gert-Jan B van Ommen, Willeke M C van Roon-Mom   +9 more
doaj   +1 more source

Cysteine String Protein Controls Two Routes of Export for Misfolded Huntingtin

Frontiers in Neuroscience, 2022
Extracellular vesicles (EVs) are secreted vesicles of diverse size and cargo that are implicated in the cell-to-cell transmission of disease-causing-proteins in several neurodegenerative diseases.
Desmond Pink, Julien Donnelier, John D. Lewis, John D. Lewis, Janice E. A. Braun   +4 more
doaj   +1 more source