Results 271 to 280 of about 5,553,804 (280)

Huntingtin is associated with cytomatrix proteins at the presynaptic terminal

Molecular and Cellular Neuroscience, 2014
Huntington's disease (HD) is a single gene disorder produced by expansion of the gene encoding huntingtin (htt), a large protein with features of a multi-functional scaffold. Expansion of htt's polyglutamine domain induces novel, toxic interactions and likely also disrupts normal htt function.
Jia Yao, Sandra M. Bajjalieh, Shao En Ong   +2 more
openaire   +3 more sources

Huntingtin protein maintains balanced energetics in mouse cardiomyocytes

Nucleosides, Nucleotides & Nucleic Acids, 2020
Huntingtin (HTT) is a multifunctional protein crucial for proper embryogenesis and nervous system development. Mutation of a single allele in gene coded this protein results in the Huntington׳s disease (HD). There is growing evidence of cardiovascular system pathologies coexisting with the neurological symptoms in HD patients.
Henning Ulrich, Talita Glaser, Ryszard T. Smolenski, Ewa M. Slominska, Marta Tomczyk   +4 more
openaire   +3 more sources

The isolation and characterization of Huntingtin interacting proteins

1998
Huntington Disease (HD) is an autosomal dominant, neurodegenerative disorder with onset normally occurring at around 40 years of age. This devastating disease is the result of the expression of a polyglutamine tract greater than 35 in a protein with unknown function.
openaire   +2 more sources

Huntingtin Polyglutamine-Dependent Protein Aggregation in Reconstituted Cells

ACS Synthetic Biology, 2017
One of the aims of synthetic biology is bottom-up construction of reconstituted human cells for medical uses. To that end, we generated giant unilamellar vesicles (GUVs) that contained a HeLa cell extract, which comprises a cell-free protein synthesis (CFPS) system.
Yuki Yamamoto, Kanta Tsumoto, Kuru Kanzawa, Tomoaki Shigeta, Hiroaki Imataka, Hiroaki Imataka, Kodai Machida, Kodai Machida   +7 more
openaire   +3 more sources

Huntingtin interacts with the receptor sorting family protein GASP2

Journal of Neural Transmission, 2006
Protein interaction networks are useful resources for the functional annotation of proteins. Recently, we have generated a highly connected protein-protein interaction network for Huntington's disease (HD) by automated yeast two-hybrid (Y2H) screening (Goehler et al., 2004). The network included several novel direct interaction partners for the disease
S. C. Horn, Heike Goehler, Erich E. Wanker, Maciej Lalowski, Anja Dröge, Ulrich Stelzl   +5 more
openaire   +3 more sources

Mutant huntingtin protein expression and blood–spinal cord barrier dysfunction in huntington disease

Annals of Neurology, 2017
Giacomo Sciacca, F. Cicchetti
semanticscholar   +1 more source

Huntingtin Interacting Protein 1

2011
openaire   +1 more source

Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

Nature Biotechnology, 2010
P. Bauer, A. Goswami, H. Wong, Misako Okuno, M. Kurosawa, Mizuki Yamada, Haruko Miyazaki, Gen Matsumoto, Y. Kino, Y. Nagai, N. Nukina   +10 more
semanticscholar   +1 more source

Arfaptin 2 regulates the aggregation of mutant huntingtin protein

Nature Cell Biology, 2002
P. Peters, K. Ning, Felipe Palacios, R. Boshans, A. Kazantsev, L. Thompson, B. Woodman, G. Bates, C. D’Souza-Schorey   +8 more
semanticscholar   +1 more source

Huntingtin protein causes mitochondrial calcium abnormalities

The Lancet, 2002
openaire   +2 more sources