Results 21 to 30 of about 19,301 (228)

Huntingtin: A Protein with a Peculiar Solvent Accessible Surface [PDF]

International Journal of Molecular Sciences, 2021
Taking advantage of the last cryogenic electron microscopy structure of human huntingtin, we explored with computational methods its physicochemical properties, focusing on the solvent accessible surface of the protein and highlighting a quite interesting mix of hydrophobic and hydrophilic patterns, with the prevalence of the latter ones.
Giulia Babbi, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio   +3 more
openalex   +3 more sources

Huntingtin Interacting Proteins and Pathological Implications

International Journal of Molecular Sciences, 2023
Huntington’s disease (HD) is caused by an expansion of a CAG repeat in the gene that encodes the huntingtin protein (HTT). The exact function of HTT is still not fully understood, and previous studies have mainly focused on identifying proteins that interact with HTT to gain insights into its function.
Li Liu, Huichun Tong, Yize Sun, Xingxing Chen, Tianqi Yang, Gongke Zhou, Xiao-Jiang Li, Shihua Li   +7 more
openaire   +2 more sources

The Evidence for the Spread and Seeding Capacities of the Mutant Huntingtin Protein in in Vitro Systems and Their Therapeutic Implications. [PDF]

Front Neurosci, 2017
Masnata M, Cicchetti F.
europepmc   +3 more sources

Molecular mechanisms of heterogeneous oligomerization of huntingtin proteins [PDF]

Scientific Reports, 2019
AbstractThere is still no successful strategy to treat Huntington’s disease, an inherited autosomal disorder associated with the aggregation of mutated forms of the huntingtin protein containing polyglutamine tracts with more than 36 repeats. Recent experimental evidence is challenging the conventional view of the disease by revealing transcellular ...
Silvia Bonfanti, Maria Chiara Lionetti, Maria Rita Fumagalli, Venkat R. Chirasani, Guido Tiana, Nikolay V. Dokholyan, Stefano Zapperi, Caterina A. M. La Porta   +7 more
openalex   +5 more sources

Full-length huntingtin is palmitoylated at multiple sites and post-translationally myristoylated following caspase-cleavage

Frontiers in Physiology, 2023
Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein.
Fanny L. Lemarié, Shaun S. Sanders, Yen Nguyen, Dale D. O. Martin, Michael R. Hayden   +4 more
doaj   +1 more source

Stimulation of NeuroD activity by huntingtin and huntingtin-associated proteins HAP1 and MLK2 [PDF]

Proceedings of the National Academy of Sciences, 2003
NeuroD (ND) is a basic helix–loop–helix transcription factor important for neuronal development and survival. By using a yeast two-hybrid screen, we identified two proteins that interact with ND, huntingtin-associated protein 1 (HAP1) and mixed-lineage kinase 2 (MLK2), both of which are known to interact with huntingtin (Htt).
Edoardo, Marcora, Katherine, Gowan, Jacqueline E, Lee   +2 more
openaire   +2 more sources

Huntingtin protein maintains balanced energetics in mouse cardiomyocytes

Nucleosides, Nucleotides & Nucleic Acids, 2020
Huntingtin (HTT) is a multifunctional protein crucial for proper embryogenesis and nervous system development. Mutation of a single allele in gene coded this protein results in the Huntington׳s disease (HD). There is growing evidence of cardiovascular system pathologies coexisting with the neurological symptoms in HD patients.
Marta Tomczyk, Talita Glaser, Henning Ulrich, Ewa M. Słomińska, Ryszard T. Smoleński   +4 more
openalex   +3 more sources

Huntington’s Disease—An Outlook on the Interplay of the HTT Protein, Microtubules and Actin Cytoskeletal Components

Cells, 2020
Huntington’s disease is a severe and currently incurable neurodegenerative disease. An autosomal dominant mutation in the Huntingtin gene (HTT) causes an increase in the polyglutamine fragment length at the protein N-terminus.
Aleksandra S. Taran, Lilia D. Shuvalova, Maria A. Lagarkova, Irina B. Alieva   +3 more
doaj   +1 more source

Detection of ubiquitinated huntingtin species in intracellular aggregates

Frontiers in Molecular Neuroscience, 2015
Protein conformation diseases, including polyglutamine diseases, result from the accumulation and aggregation of misfolded proteins. Huntington’s disease is one of nine diseases caused by an expanded polyglutamine repeat within the affected protein and ...
Katrin eJuenemann, Anne eWiemhoefer, Eric eReits   +2 more
doaj   +1 more source

Huntingtin associated protein 1 and its functions [PDF]

Cell Adhesion & Migration, 2009
Huntington disease (HD) is caused by a polyglutamine expansion in the protein huntingtin (Htt). Several studies suggest that Htt and huntingtin associated protein 1 (HAP1) participate in intracellular trafficking and that polyglutamine expansion affects vesicular transport.
Zhou, Xin-Fu, Wu, Linyan
openaire   +4 more sources