Results 71 to 80 of about 6,546,213 (228)
Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia. [PDF]
PLoS ONE, 2014 Patients with Huntington's disease exhibit memory and cognitive deficits many years before manifesting motor disturbances. Similarly, several studies have shown that deficits in long-term synaptic plasticity, a cellular basis of memory formation and ...
Yun-Beom Choi +5 more
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, 2013 Brain-derived neurotrophic factor (BDNF) polymorphism is associated with the pathophysiology of several neurodegenerative disorders, including Huntington"s disease.
Toro Ruiz, Daniel del +5 more
core +1 more source
Isolation of a 40-kDa Huntingtin-associated Protein [PDF]
Journal of Biological Chemistry, 2001 Huntington's disease is caused by an expanded CAG trinucleotide repeat coding for a polyglutamine stretch within the huntingtin protein. Currently, the function of normal huntingtin and the mechanism by which expanded huntingtin causes selective neurotoxicity remain unknown. Clues may come from the identification of huntingtin-associated proteins (HAPs)
M F, Peters, C A, Ross
openaire +2 more sources
Huntingtin Regulates Mammary Stem Cell Division and Differentiation
Stem Cell Reports, 2014 Little is known about the mechanisms of mitotic spindle orientation during mammary gland morphogenesis. Here, we report the presence of huntingtin, the protein mutated in Huntington’s disease, in mouse mammary basal and luminal cells throughout ...
Salah Elias +6 more
doaj +1 more source
Nature Communications, 2021 The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here the authors perform a detailed investigation of the ultrastructural and biochemical properties of huntingtin cytoplasmic and nuclear inclusions, and reveal that
Nathan Riguet +11 more
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Journal of Biological Chemistry, 2014 Background: Huntington disease is a fatal neuropsychiatric disorder caused by aberrant protein folding and interactions. Results: An interaction network composed of primary and secondary huntingtin-interacting proteins is significantly enriched for ...
C. Tourette +6 more
semanticscholar +1 more source
Cardiac dysfunction in the R6/2 mouse model of Huntington’s disease
Neurobiology of Disease, 2007 Recent evidence suggests that mutant huntingtin protein-induced energetic perturbations contribute to neuronal dysfunction in Huntington’s disease (HD). Given the ubiquitous expression of huntingtin, other cell types with high energetic burden may be at ...
Michael J. Mihm +5 more
doaj +1 more source
Huntington disease: Advances in the understanding of its mechanisms
Clinical Parkinsonism & Related Disorders, 2020 Huntington disease (HD) is a devastating monogenic autosomal dominant disorder. HD is caused by a CAG expansion in exon 1 of the gene coding for huntingtin, placed in the short arm of chromosome 4.
Emilia M. Gatto +5 more
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DISC1 and Huntington's disease--overlapping pathways of vulnerability to neurological disorder? [PDF]
PLoS ONE, 2011 We re-annotated the interacting partners of the neuronal scaffold protein DISC1 using a knowledge-based approach that incorporated recent protein interaction data and published literature to. This revealed two highly connected networks.
Ruth Boxall +2 more
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Structure of human NatA and its regulation by the Huntingtin Interacting Protein HYPK
Structure, 2018 Co-translational N-terminal protein acetylation regulates many protein functions including degradation, folding, interprotein interactions, and targeting.
L. Gottlieb, R. Marmorstein
semanticscholar +1 more source