Results 1 to 10 of about 36,080 (282)

Ex vivo 100 μm isotropic diffusion MRI‐based tractography of connectivity changes in the end‐stage R6/2 mouse model of Huntington's disease

Neuroprotection, 2023
Background Huntington's disease is a progressive neurodegenerative disorder. Brain atrophy, as measured by volumetric magnetic resonance imaging (MRI), is a downstream consequence of neurodegeneration, but microstructural changes within brain tissue are ...
Ashwinee Manivannan, Lesley M. Foley, T. Kevin Hitchens, Ivan Rattray, Gillian P. Bates, Michel Modo   +5 more
doaj   +2 more sources

Altered iron and myelin in premanifest Huntington's Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study

EBioMedicine, 2021
Background: Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was ...
Eileanoir B. Johnson, Christopher S. Parker, Rachael I. Scahill, Sarah Gregory, Marina Papoutsi, Paul Zeun, Katherine Osborne-Crowley, Jessica Lowe, Akshay Nair, Carlos Estevez-Fraga, Kate Fayer, Geraint Rees, Hui Zhang, Sarah J. Tabrizi   +13 more
doaj   +1 more source

Progressive alterations in white matter microstructure across the timecourse of Huntington's disease

Brain and Behavior, 2023
Background Whole‐brain longitudinal diffusion studies are crucial to examine changes in structural connectivity in neurodegeneration. Here, we investigated the longitudinal alterations in white matter (WM) microstructure across the timecourse of ...
Carlos Estevez‐Fraga, Michael S. Elmalem, Marina Papoutsi, Alexandra Durr, Elin M. Rees, Nicola Z. Hobbs, Raymund A. C. Roos, Bernhard Landwehrmeyer, Blair R. Leavitt, Douglas R. Langbehn, Rachael I. Scahill, Geraint Rees, Sarah J. Tabrizi, Sarah Gregory   +13 more
doaj   +1 more source

Case report: Cerebellar sparing in juvenile Huntington's disease

Frontiers in Neurology, 2023
Juvenile Huntington's disease is an early-onset variant of Huntington's disease, generally associated with large CAG repeats and distinct clinical symptoms. The role of the cerebellum in Huntington's disease has been reevaluated, based on the presence of
Bruno Lopes Santos-Lobato, Bruno Lopes Santos-Lobato, Jéssica Santos de Souza Rocha, Luciano Chaves Rocha   +3 more
doaj   +1 more source

Juvenile Huntington's disease: a clinical case from a pediatric's practice

Клинический разбор в общей медицине, 2023
Background. Huntington's disease (Hd) is a hereditary neurodegenerative disease with an autosomal dominant type of inheritance and manifested by motor, behavioral and mental disorders.
Emilia E. Alieva, Polina A. Klishina, Bella O. Matsukatova, Alfiya I. Aminova   +3 more
doaj   +1 more source

Memantine administration prevented chorea movement in Huntington’s disease: a case report

Journal of Medical Case Reports, 2023
Background Huntington’s disease is an autosomal dominant inherited disorder characterized by personality changes (such as irritability and restlessness) and psychotic symptoms (such as hallucinations and delusions).
Kazumasa Saigoh, Makito Hirano, Yoshiyuki Mitsui, Itsuki Oda, Atsuko Ikegawa, Makoto Samukawa, Keisuke Yoshikawa, Yuko Yamagishi, Susumu Kusunoki, Yoshitaka Nagai   +9 more
doaj   +1 more source

Neuropsychiatric Aspects of Huntington’s Disease

Psikiyatride Güncel Yaklaşımlar, 2022
Huntington’s Disease is a progressive neurodegenerative disorder inherited in an autosomal dominant fashion with distinct phenotypesas chorea and dystonia, incoordination, cognitive disorders, and behavioural problems.
Özlem Devrim Balaban, E. Cem Atbaşoğlu   +1 more
doaj   +1 more source

A Triple Insider's Take on Arts Therapy, Arts-based Community Development, and Huntington's Disease

Voices, 2015
In this article, I reflect on my experiences as someone with Huntington's Disease who works professionally as a development ethnomusicologist, and who creates musical, video, and graphic arts for healing in communities I know.
Brian Schrag
doaj   +1 more source

Bioinformatic analysis of a microRNA regulatory network in Huntington's disease [PDF]

Journal of Integrative Neuroscience, 2020
Huntington's disease is an autosomal dominant hereditary neurodegenerative disease characterized by progressive dystonia, chorea and cognitive or psychiatric disturbances.
Zhi-Min Wang, Xiao-Yu Dong, Shu-Yan Cong
doaj   +1 more source

Metacognitive insight into cognitive performance in Huntington’s disease gene carriers

BMJ Neurology Open, 2022
Objectives Insight is an important predictor of quality of life in Huntington’s disease and other neurodegenerative conditions. However, estimating insight with traditional methods such as questionnaires is challenging and subjected to limitations.
Roger A Barker, Sarah L Mason, Samuel RC Hewitt, Alice J White   +3 more
doaj   +1 more source