Results 91 to 100 of about 36,080 (282)
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
Precision therapies for genetic epilepsies in 2025: Promises and pitfalls
Epilepsia Open, EarlyView.Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang +3 more
wiley +1 more source
Studying Genetic Risk in the Conduct of Everyday Life
Outlines, 2003 This article is a revised version of a talk given in lieu of the Ph.D. dissertation: "Huntington´s Disease in Everyday Life. Knowledge, Ignorance and Genetic Risk".
Lotte Huniche
doaj
Automatic selection model to identify neurodegenerative diseases
Digital HealthObjective This study evaluates machine learning algorithms’ effectiveness in classifying Parkinson’s disease and Huntington’s disease based on biomarker data obtained non-invasively from patients and healthy controls.
Eddy Sánchez-DelaCruz +3 more
doaj +1 more source
Executive Impairment in Huntington's Disease: Insights From a Systematic Review of the Literature. [PDF]
Brain BehavExecutive dysfunction in Huntington's disease follows a selective, stage‐dependent pattern, with early deficits in psychomotor speed, cognitive flexibility, inhibition, and working‐memory updating. Progression is associated with broader impairments in planning and attention.
Migliore S +4 more
europepmc +2 more sources
Food Frontiers, EarlyView.This study highlights the memory‐enhancing effects of walnuts, almonds, and Torreya, with walnuts showing the strongest potential to improve cognitive function and delay brain aging. ABSTRACT This study explored the memory‐enhancing potential of seven commercially available nuts through nutritional profiling, metabolomics, network pharmacology, and ...
Jiamin Chen +10 more
wiley +1 more source
Gene suppression strategies for dominantly inherited neurodegenerative diseases: lessons from Huntington's disease and spinocerebellar ataxia [PDF]
, 2015 Megan S. Keiser +2 more
openalex +1 more source
Move beyond free radical theory of aging
iMetaOmics, EarlyView.Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley +1 more source
Huntington’s Disease and Psychiatric Comorbidities: A Retrospective Study in Portugal
Acta Médica PortuguesaIntroduction: Huntington’s disease is a progressive neurodegenerative disorder characterized by motor, cognitive, and behavioral symptoms. While psychiatric comorbidity is common and may influence disease outcomes, there is a lack of data on its ...
José Rocha +2 more
doaj +1 more source