Results 11 to 20 of about 32,987 (207)
A 24-Hour Study of the Hypothalamo-Pituitary Axes in Huntington's Disease. [PDF]
PLoS ONE, 2015 Huntington's disease is an inherited neurodegenerative disorder characterised by motor, cognitive and psychiatric disturbances. Patients exhibit other symptoms including sleep and mood disturbances, muscle atrophy and weight loss which may be linked to ...
Eirini Kalliolia +10 more
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Proteostasis in striatal cells and selective neurodegeneration in Huntington’s disease
Frontiers in Cellular Neuroscience, 2014 Selective neuronal loss is a hallmark of neurodegenerative diseases, including Huntington’s disease (HD). Although mutant huntingtin, the protein responsible for Huntington’s disease, is expressed ubiquitously, a subpopulation of neurons in the striatum ...
Julia eMargulis +4 more
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Monkey hybrid stem cells develop cellular features of Huntington's disease
BMC Cell Biology, 2010 Background Pluripotent stem cells that are capable of differentiating into different cell types and develop robust hallmark cellular features are useful tools for clarifying the impact of developmental events on neurodegenerative diseases such as ...
Lorthongpanich Chanchao +9 more
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EBioMedicine, 2021 Background: Pathological processes in Huntington's disease (HD) begin many years prior to symptom onset. Recently we demonstrated that in a premanifest cohort approximately 24 years from predicted disease onset, despite intact function, there was ...
Eileanoir B. Johnson +13 more
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Targeting several CAG expansion diseases by a single antisense oligonucleotide. [PDF]
PLoS ONE, 2011 To date there are 9 known diseases caused by an expanded polyglutamine repeat, with the most prevalent being Huntington's disease. Huntington's disease is a progressive autosomal dominant neurodegenerative disorder for which currently no therapy is ...
Melvin M Evers +7 more
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PLoS ONE, 2015 Huntington's disease is a fatal neurodegenerative condition caused by a CAG repeat expansion in the huntingtin gene. The peripheral innate immune system is dysregulated in Huntington's disease and may contribute to its pathogenesis.
James R C Miller +3 more
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Revista Finlay, 2023 Foundation: biomarkers of oxidative stress in Huntington's disease could predict the course of the disease and evaluate new treatments, but their nonspecific nature seems to prevent the identification of any useful marker.
Marisol Peña Sánchez +5 more
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Premanifest Huntington's disease: Examination of oculomotor abnormalities in clinical practice. [PDF]
PLoS ONE, 2018 Different oculomotor abnormalities have been reported to occur in premanifest Huntington's disease. The aim of this study is to investigate which oculomotor items of the Unified Huntington's Disease Rating Scale (UHDRS) are affected in premanifest ...
Jessica Y Winder, Raymund A C Roos
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Huntington’s disease: Neuropsychiatric manifestations of Huntington’s disease [PDF]
Australasian Psychiatry, 2018 Objectives: Huntington’s disease (HD) is a profoundly incapacitating, and ultimately fatal, neurodegenerative disease. HD is presently incurable, so the current goal is to allow affected individuals to live as well as possible with the illness, to maximise functional independence and quality of life for the person with HD, their carers and family ...
Anita MY Goh +5 more
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Silencing Huntington's chorea: Is RNA Interference a Potential Cure? [PDF]
Impulse: The Premier Undergraduate Neuroscience Journal, 2006 In 1872, George Huntington described Huntington's disease as characterized by motor, cognitive and psychiatric impairments. Huntington's disease is a dominant and autosomal mutation on chromosome 4 featuring the insertion of numerous CAG repeats.
Gerlinde A. Metz +3 more
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