Results 221 to 230 of about 37,609 (272)

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease. [PDF]

Ann Clin Transl Neurol
Chelsky D, Joyce C, Bockholt HJ, Rudnick PA, Adams WH, McAllister F, Smock JW, Newton MA, Paulsen JS.   +8 more
europepmc   +1 more source

LRRK2 Mutation Alters Dopamine D2 Receptor Localization in Induced Pluripotent Stem Cells‐Derived Astrocytes From Parkinson's Disease Patients: Implications for Neuronal Damage

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
In this study, human astrocytes were obtained from induced pluripotent stem cells (iPSCs) of Parkinson's disease (PD) patients carrying the G2019S LRRK2 mutation, the most common genetic cause of PD. These astrocytes display a reactive and inflammatory profile, with increased GFAP levels, elevated cytokine release, and reduced support for dopaminergic ...
Veronica Mutti, Federica Bono, Zaira Tomasoni, Dounia Fadel, Chiara Gnutti, Giulia Sbrini, Carolina Gaudenzi, Valentina Salvi, Daniela Bosisio, Isabella Russo, Silvia Bolognin, Jens C. Schwamborn, Cristina Missale, Chiara Fiorentini   +13 more
wiley   +1 more source

Huntington's Disease-Like 2 in a European Caucasian Patient. [PDF]

Mov Disord Clin Pract
Rodrigues CC, Antunes AP, Oliveira J, Freixo JP, Guedes LC, Carvalho V.   +5 more
europepmc   +1 more source

From Synapses to Circuits, the Role of KIBRA and the WWC Family in Adaptive Brain Function

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
KIBRA (WWC1) has been the subject of scientific interest since its initial association with nonpathological variation in human memory performance. This review discusses subsequent work in animal models demonstrating that KIBRA supports memory function.
Lenora J. Volk
wiley   +1 more source

Brain organoid models of Huntington's disease shift the focus towards neurodevelopment. [PDF]

Dis Model Mech
Xu W, Prigione A.
europepmc   +1 more source

Phase Separation Drives Pathological Aggregation in Neurodegenerative Diseases: A 15‐Year Bibliometric Landscape (2009–2024)

Annals of the New York Academy of Sciences, Volume 1561, Issue 1, July 2026.
This 15‐year bibliometric study (2009–2024) characterizes the global landscape of liquid–liquid phase separation (LLPS) in neurodegenerative diseases. We delineate the field's evolution from fundamental biophysics to clinical translation, emphasizing the liquid‐to‐solid transition of proteins like TDP‐43, tau, and α‐synuclein.
Chanyuan Zhang, Siyao Chen, He Zhao, Yan Wang, Lingyan Zhou, Haixia Fan, Yan Sun   +6 more
wiley   +1 more source

Mutant huntingtin expression in somatostatin-positive interneurons contributes to neurophysiological and behavioral phenotypes in BACHD mice

Disease Models & Mechanisms
Jahmel A. Fowler, Mariangela Scarduzio, Cayla Pool, Casey D. Mahan, Michelle Gray   +4 more
doaj   +1 more source

Temporal Muscle Thickness Correlates with Functional Decline in Huntington's Disease. [PDF]

Mov Disord
Hemicker G, Cerejo C, Peball M, Schwarzová K, Carbone F, Wimmer B, Krismer F, Mahlknecht P, Djamshidian A, Grams AE, Labrecque S, Seppi K, Heim B.   +12 more
europepmc   +1 more source

Mapping Functionally Relevant Tractable Lysines of Challenging Protein Targets by Covalent Fragment Screening

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Screening a lysine‐targeting covalent fragment library against challenging protein targets revealed suitable warheads and characterized binding sites for the development of targeted covalent ligands. Covalent fragment screening has become an established strategy for identifying targetable amino acid residues or viable chemical starting points against ...
Noémi Csorba, Péter Ábrányi‐Balogh, Zoltán Orgován, Tibor Viktor Szalai, György G. Ferenczy, Levente Kollár, Nikolett Péczka, Tímea Imre, József Simon, Pál Szabó, Gitta Schlosser, Martina Hrast, Stanislav Gobec, Varbina Ivanova, Carles Galdeano, Aleksandra Kopranovic, Marc Neumann, Franz‐Josef Meyer‐Almes, György Miklós Keserű   +18 more
wiley   +1 more source

Effect of tetrabenazine on Stroop interference in Huntington's disease: Protocol. [PDF]

MethodsX
Fekete R.
europepmc   +1 more source