I'll Be Dammed: Efficiency and Cost‐Analysis of a Rehabilitated Prehispanic Dam in the Andes
ABSTRACT Within archaeology there is a growing shift away from the purely aesthetic towards making the past relevant to present and future needs and demands. The Past Water Futures project charts the impact of ancient dam rehabilitation on climate change‐induced water scarcity in the North Central Andes.
Kevin Lane +5 more
wiley +1 more source
Co-Design of a New Integrated Care Model With People Affected by Huntington's Disease: A Mixed Methods Study. [PDF]
Pires SB +5 more
europepmc +1 more source
Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers
This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai +10 more
wiley +1 more source
Correction: F2,6BP restores mitochondrial genome integrity in Huntington's disease. [PDF]
Chakraborty A +13 more
europepmc +1 more source
ABSTRACT Branched‐chain amino acids (BCAA) and their corresponding keto acids (BCKA) have been associated with changes in hepatic lipid metabolism and the resulting alterations in intracellular triglyceride concentrations. In this study, we utilized a previously established hepatocyte model to investigate the impact of BCAA and BCKA supplementation on ...
Jayasimha R. Daddam +4 more
wiley +1 more source
The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo +11 more
wiley +1 more source
In this descriptive pilot study, short‐term (5‐day) high‐dose firocoxib (1.0 mg/kg) was not associated with detectable gastric mucosal injury in horses. Due to non‐randomised design and small sample size (n = 5/group), no causal conclusions can be drawn. Findings are hypothesis‐generating and require confirmation in adequately powered trials.
Renato Abrantes de Oliveira +3 more
wiley +1 more source
Sequential Clinical Changes Following Autologous Mesenchymal Stem Cell Therapy in a Patient With Concurrent Huntington's Disease and Ankylosing Spondylitis: A Case Report. [PDF]
Gurskaia R.
europepmc +1 more source
This review systematically elucidates the multifactorial anti‐aging mechanisms of extracellular vesicles (EVs). By bridging fundamental biology with advanced bioengineering, scalable manufacturing, and clinical translation, it establishes a comprehensive framework for developing next‐generation EVs‐based precision nanotherapeutics to combat systemic ...
Xian Huang +6 more
wiley +1 more source
Development and Validation of a Brief Fall Questionnaire (FALL-HD) for Patients with Huntington's Disease. [PDF]
Kaur J +7 more
europepmc +1 more source

