Results 191 to 200 of about 4,891,805 (263)

Clinical implications of loss of interruption variants for diagnosis, genetic counselling, and clinical trials in Huntington's disease. [PDF]

J Huntingtons Dis
Findlay Black H, Levesley J, Kay C, Bortnick S, Javier K, Hayden MR.   +5 more
europepmc   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Exploring the association between antidepressants, progression and mortality in Huntington's disease. [PDF]

Brain
McLauchlan D, Drew C, Holmans P, Rosser A.   +3 more
europepmc   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Assessing the efficacy of dextromethorphan/quinidine in treating irritability in Huntington's disease. [PDF]

J Huntingtons Dis
Zadegan SA, Calderon O, Karagas N, Patino J, Dongarwar D, Duncan B, Teixeira AL, Rocha NP, Furr Stimming E.   +8 more
europepmc   +1 more source

Organoids: Current Applications and Future Directions

MedComm, Volume 7, Issue 10, October 2026.
Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human development and disease mechanisms, drug ...
Yueqi Leng, Yue Wang, Canhui Cao, Feng Deng, Weisi Lian, Xingtong Chen, Mingmei Lin, Zhonghong Zeng, Dan Mo, Shangqi Li, Yilei He, Yang Yu, Heng Pan, Ping Zhou, Rong Li   +14 more
wiley   +1 more source

Huntington's disease clinical trials update: October 2025. [PDF]

J Huntingtons Dis
Farag M, Tabrizi SJ, Wild EJ.
europepmc   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Animal models of Huntington's disease. Pros and cons. [PDF]

Brain Behav Immun Health
Stepanova P, Voutilainen MH, Eriksson O, Lindholm D.   +3 more
europepmc   +1 more source

The Adult Aedes aegypti Bacterial Microbiota is Robust to Infection with the Obligate Microsporidian Parasite Edhazardia aedis

Environmental Microbiology, Volume 28, Issue 10, October 2026.
In ‘The adult Aedes aegypti microbiota is robust to infection with the microsporidian parasite Edhazardia aedis’, Dom Magistrado and Sarah M. Short* use high‐throughput 16S amplicon sequencing to reveal that in contrast to a multitude of other bacterial, viral, and microsporidian pathogens, infection with the microsporidian pathogen E.
Dom Magistrado, Sarah M. Short
wiley   +1 more source