Results 211 to 220 of about 57,910 (287)

Psychosocial Impacts of Huntington's Disease on Individuals, Relatives and Family Systems: A Thematic Synthesis. [PDF]

Clin Genet
Lindo P, Tindall T, Buswell S, Lock S, Gunn S.   +4 more
europepmc   +1 more source

Quality control of protein import into mammalian mitochondria

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Mitochondrial function depends on the continuous import of hundreds of nuclear‐encoded proteins. Targeting and translocation of mitochondrial proteins is a multistep process that is inherently vulnerable to defects in cytosolic quality control systems as well as perturbations in mitochondrial protein import machinery and organelle function ...
Madeleine Goldstein, Laurie Lee‐Glover, Hilla Weidberg   +2 more
wiley   +1 more source

Stage-Dependent Inhibitory Connectivity in Striatal-Motor Circuit in Huntington's Disease. [PDF]

Ann Clin Transl Neurol
Jing Y, Dogan I, Overbeck RT, Reetz K, Romanzetti S.   +4 more
europepmc   +1 more source

The effects of silencing insulins on the morphology and function of both healthy and degenerate mechanosensory neurons in the C. elegans aging model [PDF]

, 2013
Currey, Heather, Hunter, Skyler
core  

Evaluating Protein Enrichment Methods to Improve Biomarker Discovery in Equine Cerebrospinal Fluid

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Here, we compared two protein enrichment methods—ProteoMiner Small‐Capacity and PreOmics Enrich‐iST—for proteomic analysis of equine cerebrospinal fluid (CSF). PreOmics Enrich‐iST achieved superior depletion of high‐abundance proteins and identified a greater number of low‐abundance, neuropathology‐relevant proteins than ProteoMiner or native digestion.
Foti Federico, Wilson Amie, Chabronova Alzbeta, Jensen Anders, Lunn Paul David, Peffers Jayne Mandy   +5 more
wiley   +1 more source

Discovery of disrupted sustained attention and altered functional connectivity in far-from-onset Huntington's disease gene-expanded young adults. [PDF]

Alzheimers Dement
Langley C, Leocadi M, Hobbs NZ, Farag M, Murphy MJ, Fayer K, Scahill RI, Rowe JB, Robbins TW, Tabrizi SJ, Sahakian BJ.   +10 more
europepmc   +1 more source

Re‐Evaluating Hot Mitochondria: Too Slow to Cool

Acta Physiologica, Volume 242, Issue 5, May 2026.
ABSTRACT Aim Mito Thermo Yellow (MTY) is a mitochondrially targeted fluorophore that shows marked fluorescence quenching with increasing temperature, allowing for interrogating temperature dynamics in the mitochondria of live cells. Here we re‐evaluate published MTY fluorescence responses used to argue in favor of the ‘hot mitochondria’ concept; the ...
Jason R. Treberg, Ryan J. Mailloux
wiley   +1 more source

Huntington's Disease Research Over Six Decades: Global Insights, Gaps, and Future Directions. [PDF]

Cureus
Masna H, Konda M, Ganti L.
europepmc   +1 more source

Death anxiety predicts fear of progression in people with rheumatic conditions

British Journal of Health Psychology, Volume 31, Issue 2, May 2026.
Abstract Background Rheumatic diseases often have a progressive course and place individuals at increased risk of mortality. Despite this, little research has investigated the relationship between death anxiety and fears about disease progression (FoP), and how these might relate to health‐related quality of life (HRQoL) outcomes.
Bethany Richmond, Louise Sharpe, Jack B. Boyse, Joanne Shaw, Rachel E. Menzies   +4 more
wiley   +1 more source

Cognitive Endpoints in Huntington's Disease Trials: A Conceptual Framework for Clinical Meaningfulness. [PDF]

Mov Disord Clin Pract
Roiboit CM, Stout JC.
europepmc   +1 more source