Results 211 to 220 of about 37,609 (272)

A Non‐Canonical Role for Hepatocyte MLKL in Promoting Mitochondrial Dysfunction and Senescence in the Aging Liver

Aging Cell, Volume 25, Issue 7, July 2026.
Aging‐associated MLKL upregulation in hepatocytes induces mitochondrial dysfunction and oxidative stress, accompanied by increased release of pro‐inflammatory extracellular vesicles. These changes are associated with increased p16+/p21+ senescence in hepatocytes and non‐parenchymal cells (macrophages, stellate cells, and endothelial cells), suggesting ...
Sabira Mohammed, Chao Jiang, Travis Pennington, Shylesh Bhaskaran, Phoebe Ohene‐Marfo, Kara F. Kneuper, Constantin Georgescu, Kamille Pitts, Albert Tran, Zongkai Peng, Amit Singh, Zhibo Yang, Tiangang Li, Bethany Hannafon, Courtney Houchen, Jonathan D. Wren, Andriy Yabluchanskiy, Veronica Galvan, Nagib Ahsan, Michael Kinter, Tommy L. Lewis Jr, Sathyaseelan S. Deepa   +21 more
wiley   +1 more source

Neuronal mitochondrial disaggregase CLPB ameliorates Huntington's disease pathology in mice. [PDF]

Theranostics
Kim H, Hyun G, Kim S, Yu C, Hong YG, Yu J, Bae S, Rhee HW, Ko J, Um JW.   +9 more
europepmc   +1 more source

Rapid generation of prion disease models using AAV‐delivered PrP variants in knockout mice

Brain Pathology, Volume 36, Issue 4, July 2026.
We developed a rapid AAV‐based system to generate prion disease models in weeks rather than months. Following systemic AAV9P31 delivery of modified PrP to knockout mice, we achieved brain‐wide expression and successful propagation of both classical (RML) and atypical (GSS‐A117V) prion strains.
Maitena San‐Juan‐Ansoleaga, Eva Fernández‐Muñoz, Jorge M. Charco, Enric Vidal, Diego Herrero‐Martínez, Josu Galarza‐Ahumada, Cristina Sampedro‐Torres‐Quevedo, Samanta Giler, Mariví Geijo, Gloria González‐Aseguinolaza, Hasier Eraña, Joaquín Castilla   +11 more
wiley   +1 more source

Economic Cost of Current and Alternative Models of Multidisciplinary Care of Juvenile-Onset Huntington's Disease. [PDF]

Mov Disord Clin Pract
Young TA, Curtis PA, Thompson J, Ho AK, Santini H, Quarrell OW.   +5 more
europepmc   +1 more source

Clinical‐Grade Human Induced Pluripotent Stem Cell‐Derived Neural Precursor Cells Restore Motor Function and Preserve Striatal Integrity in a Quinolinic Acid‐Lesioned Rat Model of Huntington's Disease

Cell Proliferation, Volume 59, Issue 7, July 2026.
Clinical‐grade HLA‐homozygous iPSC‐derived neural precursor cells restore motor function, rebuild striatal circuitry and reduce neuroinflammation in QA‐lesioned rats. These findings demonstrate robust neuronal replacement and microenvironment modulation, supporting their potential as a regenerative therapy for Huntington's disease.
Hyeonjoong Jeon, Il‐Shin Lee, Sanghun Lee, Hyo Chang Park, Beomsoo Kim, Hyun Sook Kim, Jihwan Song   +6 more
wiley   +1 more source

Emotion recognition in people with Huntington's disease: A comprehensive systematic review. [PDF]

J Huntingtons Dis
Zarotti N, Storey A, Lloyd S, Guevara LM, Caswell H, Chen C, Simpson J.   +6 more
europepmc   +1 more source

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Corrigendum to "Animal models of Huntington's disease. Pros and cons" [Brain, Behavior, Immunity Health 50 (2025) 101149. [PDF]

Brain Behav Immun Health
Stepanova P, Eriksson O, Voutilainen MH, Lindholm D.   +3 more
europepmc   +1 more source

PGK1 Drives Glial Glycolytic Reprogramming to Mediate Isoflurane‐Induced Cognitive Impairment in Aged Mice

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Isoflurane‐induced neuroinflammation triggers cognitive impairment in aged mice, but its underlying mechanism remains unclear. This study investigated the molecular mechanism by which isoflurane promotes glycolytic reprogramming to cause cognitive dysfunction in aged mice and identified potential therapeutic targets.
Zhuo Ren, Huaying Hu, Jiahao Guo, Yajun Liu, Chenyang Qiu, Kai Yuan, Yujie Ma, Shuntao Jiao, Ruiyun Guo, Dengfa Zhao, Dongliang Zhang, Yang Zeng, Jun Ma, Mianwang He   +13 more
wiley   +1 more source