Results 81 to 90 of about 36,080 (282)

Huntington’s disease: Managing neuropsychiatric symptoms in Huntington’s disease

Australasian Psychiatry, 2018
Objectives:This clinical update review focuses on the management of the neuropsychiatric manifestations of Huntington’s disease (HD). The review highlights current issues regarding pharmacological and non-pharmacological treatment, putative therapeutics and recent relevant research findings in this area.Conclusions:Neuropsychiatric symptoms may precede
Samantha M Loi, Mark Walterfang, Dennis Velakoulis, Jeffrey CL Looi   +3 more
openaire   +3 more sources

A Core Head, Neck, and Neuroanatomy Syllabus for Physical Therapy Student Education

Clinical Anatomy, EarlyView.
ABSTRACT Head, neck, and neuroanatomy are essential components of physical therapy education due to their broad clinical applications. Detailed syllabi exist for medical students, yet none have been developed for physical therapy. This study aimed to produce an International Federation of Associations of Anatomists core head, neck, and neuroanatomy ...
Stephanie J. Woodley, Brooke Willoughby, Alexandra L. Webb, Natasha A. M. S. Flack, Laura Y. Whitburn   +4 more
wiley   +1 more source

Mitochondria and the Actin Cytoskeleton in Neurodegeneration

Cytoskeleton, EarlyView.
ABSTRACT Mitochondrial dysfunction and cytoskeletal disorganization are widely recognized hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS).
Shivani Tuli, Preet Patel, Aneri Shethji, David Gau   +3 more
wiley   +1 more source

Bioinformatics analysis of the molecular mechanism underlying Huntington's disease

Journal of Integrative Neuroscience, 2019
We explore the underlying molecular mechanisms and to identify key molecules in Huntington's disease by utilizing bioinformatics methods. The gene expression profile of GSE3621 was extracted from the gene expression omnibus.
Zhimin Wang, Xiaoyu Dong, Shuyan Cong
doaj   +1 more source

Effects of High‐ and Low‐Fat Meals on the Bioavailability and Pharmacokinetics of Votoplam, a HTT Gene Splicing Modifier

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Votoplam is a novel, orally bioavailable, small molecule HTT gene splicing modifier that is being developed for the treatment of Huntington's disease. This was a single dose, open‐label, two‐period, crossover food effect study that evaluated the effect of high‐ and low‐fat meals on 20 mg votoplam in healthy participants. There was a washout of
Lucy Lee, Amy‐Lee Richards, Nageswara Reddy, Brian Beers, Lee Golden, Ronald Kong   +5 more
wiley   +1 more source

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients [PDF]

, 2017
Luisa Quinti, Sharadha Dayalan Naidu, Ulrike Träger, Xiqun Chen, Kimberly B. Kegel-Gleason, David Llères, Colúm Connolly, Vanita Chopra, Cho Low, S. Moniot, Ellen Sapp, Adelaide Tousley, Petr Vodička, Michael J. Van Kanegan, Linda S. Kaltenbach, Lisa A. Crawford, Matthew Fuszard, Maureen Higgins, James R. C. Miller, Ruth Farmer, Vijay Potluri, Susanta Samajdar, Lisa Meisel, Ningzhe Zhang, Andrew R. Snyder, Ross L. Stein, Steven M. Hersch, Lisa Ellerby, Eranthie Weerapana, Michael A. Schwarzschild, Clemens Steegborn, Blair R. Leavitt, Alexei Degterev, Sarah J. Tabrizi, Donald C. Lo, Marian DiFiglia, Leslie M. Thompson, Albena T. Dinkova‐Kostova, Aleksey Kazantsev   +38 more
openalex   +1 more source

A2A Adenosine Receptor Agonists With Last‐Step Enzymatic 18F‐Labelling Potential (Fluorinase) for Positron Emission Tomography (PET)

European Journal of Organic Chemistry, EarlyView.
This study exploits the comparable binding tolerances between the fluorinase enzyme and the A2A adenosine receptor towards the development of novel C‐2 functionalised 5′‐fluorodeoxy‐adenosine (FDA)‐based agonists with enzymatic 18F‐labelling capability for positron emission tomography (PET).
Nicolas Charalambous, Carina Schleidt, Rongfang Liu, Laura H. Heitman, Sergio Dall’Angelo, David O’Hagan, Phillip T. Lowe   +6 more
wiley   +1 more source

Striato-cortical connectivity patterns predict clinical profiles in Huntington’s disease

NeuroImage: Clinical
Background: Huntington’s disease is an inherited neurodegenerative disorder affecting striato-cortical circuits, with significant heterogeneity in the severity and progression of symptoms and neurodegenerative patterns.
Audrey E. De Paepe, Vasiliki Bikou, Eylül Turan, Alexis Pérez-Bellido, Clara Garcia-Gorro, Nadia Rodriguez-Dechicha, Irene Vaquer, Matilde Calopa, Ruth de Diego-Balaguer, Estela Camara   +9 more
doaj   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Semiology and determinants of apathy across neurodegenerative motor disorders: A comparison between amyotrophic lateral sclerosis, Parkinson's and Huntington's disease

, 2023
Barbara Poletti, Federica Solca, Sabrina Maffi, Silvia Torre, Laura Carelli, Edoardo Nicolò Aiello, Roberta Ferrucci, Alberto Priori, Alessia Monti, Federico Verde, Nicola Ticozzi, Simone Migliore, Eugenia Scaricamazza, Melissa Casella, Ferdinando Squitieri, Andrea Ciammola, Vincenzo Silani   +16 more
openalex   +1 more source