Results 1 to 10 of about 9,364,929 (305)

Huntington disease exacerbates action impulses [PDF]

Frontiers in Psychology, 2023
BackgroundImpulsivity is a common clinical feature of Huntington disease (HD), but the underlying cognitive dynamics of impulse control in this population have not been well-studied.ObjectiveTo investigate the temporal dynamics of action impulse control ...
Shuhei Shiino, Nelleke Corine van Wouwe, Scott A. Wylie, Daniel O. Claassen, Katherine E. McDonell   +4 more
doaj   +2 more sources

Mitochondrial and Redox Modifications in Huntington Disease Induced Pluripotent Stem Cells Rescued by CRISPR/Cas9 CAGs Targeting [PDF]

Frontiers in Cell and Developmental Biology, 2020
Mitochondrial deregulation has gained increasing support as a pathological mechanism in Huntington’s disease (HD), a genetic-based neurodegenerative disorder caused by CAG expansion in the HTT gene. In this study, we thoroughly investigated mitochondrial-
Carla Lopes, Carla Lopes, Yang Tang, Yang Tang, Sandra I. Anjo, Sandra I. Anjo, Bruno Manadas, Isabel Onofre, Isabel Onofre, Luís P. de Almeida, Luís P. de Almeida, George Q. Daley, George Q. Daley, George Q. Daley, George Q. Daley, Thorsten M. Schlaeger, Thorsten M. Schlaeger, Ana Cristina Carvalho Rego, Ana Cristina Carvalho Rego   +18 more
doaj   +2 more sources

Bariatric surgery and semaglutide in a youth with juvenile Huntington disease and severe obesity: a case report [PDF]

Journal of Medical Case Reports
Background Managing severe obesity in youth with chronic, progressive conditions, such as juvenile Huntington disease, presents unique challenges. Juvenile Huntington disease, is characterized by rapid neurodegeneration, with most patients experiencing a
Alaina P. Vidmar, Matthew J. Martin, Stuart Abel, Aimee G. Kim, Cynthia E. Muñoz, Madeleine Weitzner, Sabrina F. Derrington, Kamran Samakar   +7 more
doaj   +2 more sources

Huntington disease

Nature Reviews Disease Primers, 2015
Gillian P Bates, James F Gusella, Michael R Hayden   +2 more
exaly   +3 more sources

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Nature Genetics, 2004
Brinda Ravikumar, Shou-Qing Luo, Rainer Duden   +2 more
exaly   +2 more sources

Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

Disease Models & Mechanisms, 2022
Sai S. Pradhan, Sai M. Thota, Saiswaroop Rajaratnam, Sai K. S. Bhagavatham, Sujith K. Pulukool, Sriram Rathnakumar, Kanikaram S. Phalguna, Rajesh B. Dandamudi, Ashish Pargaonkar, Prasanth Joseph, E. V. Joshy, Venketesh Sivaramakrishnan   +11 more
doaj   +2 more sources

Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease [PDF]

Human Molecular Genetics, 2003
Elizabeth Slow
openalex   +2 more sources

Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder in Huntington Disease Patient with Improvement in Neuropsychiatric and Movement Symptoms: A Case Report [PDF]

Case Reports in Neurology
Introduction: Huntington disease (HD) is a progressive disorder characterized by significant neurodegeneration that results in severe neuropsychiatric symptoms and disordered movement.
Cheyenne Rahn, Kris Peterson, Elizabeth Lamb   +2 more
doaj   +2 more sources

Reading Between the Striatal Lines: Magnetic Resonance Imaging Insights Into Huntington Disease. [PDF]

Ochsner J
Boothe R, Houghton DJ, Milburn J.
europepmc   +3 more sources

The BACHD Rat Model of Huntington Disease Shows Signs of Fronto-Striatal Dysfunction in Two Operant Conditioning Tests of Short-Term Memory. [PDF]

PLoS ONE, 2017
The BACHD rat is a recently developed transgenic animal model of Huntington disease, a progressive neurodegenerative disorder characterized by extensive loss of striatal neurons.
Erik Karl Håkan Clemensson, Laura Emily Clemensson, Olaf Riess, Huu Phuc Nguyen   +3 more
doaj   +1 more source