Results 21 to 30 of about 39,354 (231)
Experience of experimental simulation of Huntington’s disease
Анналы клинической и экспериментальной неврологии, 2017 Huntingtons disease (HD) is an autosomal dominant neurodegenerativedisease characterized by choreic hyperkinesia, cognitivedecline, behavioral disorders, and progressive neuronaldeath affecting primarily the striatum.
A. V. Stavrovskaya +5 more
doaj +1 more source
Circulating hsa-miR-323b-3p in Huntington's Disease: A Pilot Study
Frontiers in Neurology, 2021 The momentum of gene therapy in Huntington's disease (HD) deserves biomarkers from easily accessible fluid. We planned a study to verify whether plasma miRNome may provide useful peripheral “reporter(s)” for the management of HD patients. We performed an
Michela Ferraldeschi +19 more
doaj +1 more source
CellsElectroencephalogram (EEG) studies have suggested compensatory brain overactivation in cognitively healthy (CH) older adults with pathological beta-amyloid(Aβ42)/tau ratios during working memory and interference processing.
Vincent Sonny Leong +5 more
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A case report of juvenile Huntington disease
Journal of Pediatric and Neonatal Individualized Medicine, 2017 Huntington disease (HD) is a progressive neurodegenerative disorder, characterized by autosomal dominant inheritance, movement disorder, dementia, and behavioural disturbances.
Anita Choudhary +2 more
doaj +1 more source
Frontiers in Physiology, 2023 Introduction: Huntington disease is an autosomal dominant neurodegenerative disorder which is caused by a CAG repeat expansion in the HTT gene that codes for an elongated polyglutamine tract in the huntingtin (HTT) protein.
Fanny L. Lemarié +4 more
doaj +1 more source
Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi +19 more
wiley +1 more source
Parkinsonism with a Hint of Huntington’s from 29 CAG Repeats in HTT
Brain Sciences, 2019 Huntington’s disease is caused by at least 36 cytosine-adenine-guanine (CAG) repeats in an HTT gene allele, but repeat tracts in the intermediate range (27−35 repeats) also display a subtle phenotype. This patient had a slightly elongated CAG
Sipilä JOT
doaj +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
Huntington’s disease: Neuropsychiatric manifestations of Huntington’s disease [PDF]
Australasian Psychiatry, 2018 Objectives: Huntington’s disease (HD) is a profoundly incapacitating, and ultimately fatal, neurodegenerative disease. HD is presently incurable, so the current goal is to allow affected individuals to live as well as possible with the illness, to maximise functional independence and quality of life for the ...
Anita MY Goh +5 more
openaire +3 more sources
Palliative Care in Huntington Disease: Personal Reflections and a Review of the Literature
Tremor and Other Hyperkinetic Movements, 2017 Background Huntington disease is a fatal, autosomal dominant, neurodegenerative disorder manifest by the triad of a movement disorder, behavioral disturbances, and dementia.
Christopher G. Tarolli +2 more
doaj +1 more source