Results 91 to 100 of about 127,473 (295)
Drug Delivery, 2018 Neurodegenerative movement disorders mainly include Parkinson’s disease, atypical parkinsonisms, Huntington disease, and hereditary ataxia. Riluzole is the only drug approved by the US Food and Drug Administration for amyotrophic lateral sclerosis.
Jia Liu, Lu-Ning Wang
doaj +1 more source
Rodent genetic models of Huntington disease
Neurobiology of Disease, 2008 Huntington disease (HD) is a dominantly inherited human neurodegenerative disorder characterized by motor deficits, cognitive impairment, and psychiatric symptoms leading to inexorable decline and death.
Mary Y. Heng +2 more
doaj +1 more source
Distinguishing wet from dry age-related macular degeneration using three-dimensional computer-automated threshold Amsler grid testing [PDF]
, 2011 Background/aims: With the increased efficacy of current therapy for wet age-related macular degeneration (AMD), better ways to detect wet AMD are needed.
Bababeygy, Simon R. +5 more
core +1 more source
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
Biological Reviews, EarlyView.ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
Longitudinal Beta-Binomial Modeling using GEE for Over-Dispersed Binomial Data [PDF]
, 2016 Longitudinal binomial data are frequently generated from multiple questionnaires and assessments in various scientific settings for which the binomial data are often overdispersed.
Long, Jeffrey D. +2 more
core +1 more source
Enfermedad de Huntington: estado del arte [PDF]
, 2014 La enfermedad de Huntington es un desorden monogenético autosómico dominante, que genera un trastorno neurodegenerativo caracterizado por la pérdida de neuronas en diferentes partes del cerebro.
Rodas Sepúlveda, Carlos Daniel +1 more
core
Quantitative Analysis of Cytologic Features: Application to Mucoepidermoid Carcinoma
Diagnostic Cytopathology, EarlyView.ABSTRACT Introduction Cytologic diagnosis relies on recognition of morphologic features, yet the diagnostic value of individual cytologic features or their combinations is rarely quantified. In this study, we apply a quantitative cytologic feature analysis (QCFA) approach that treats each cytologic feature as a diagnostic test with measurable ...
John Effat Bacilious Diks +3 more
wiley +1 more source
Brain Sciences, 2014 Huntington disease and other diseases of polyglutamine expansion are each caused by a different protein bearing an excessively long polyglutamine sequence and are associated with neuronal death.
Guylaine Hoffner, Philippe Djian
doaj +1 more source
Multiple discrete soluble aggregates influence polyglutamine toxicity in a Huntington\u27s disease model system [PDF]
, 2016 Huntington’s disease (HD) results from expansions of polyglutamine stretches (polyQ) in the huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death.
Denis, Clyde L., Wang, Xin, Xi, Wen
core +1 more source
ELECTROPHORESIS, EarlyView.This review provides a comprehensive summary of monoamine neurotransmitter analysis by capillary electrophoresis with amperometric detection. Fundamental principles of amperometric detection, electrode positioning strategies, and approaches to high‐voltage decoupling are described, followed by a critical comparison of electrode materials, selection of ...
Petr Kubáň +3 more
wiley +1 more source