Results 141 to 150 of about 127,473 (295)

Huntington Disease [PDF]

open access: yesJournal of the Royal Society of Medicine, 2005
openaire   +2 more sources

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi   +12 more
wiley   +1 more source

The Neuroprotective Effect of a Waste Byproduct Obtained From Pomegranate (Punica granatum)

open access: yesPhytotherapy Research, EarlyView.
The Effect of a Waste Byproduct Obtained From Pomegranate on Neurodegeneration. ABSTRACT Pomegranate is an exceptional fruit that can have several beneficial effects on human health. The peel of pomegranate, a waste product, should be recovered as it still contains valuable constituents, including phenolic compounds, minerals and fibre. The recovery of
Jessica Maiuolo   +11 more
wiley   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco   +6 more
wiley   +1 more source

Advances in cholesterol and lipoproteins detection for healthcare: A review

open access: yesVIEW, EarlyView.
Cholesterol is one of the main biomarkers related to the development of cardiovascular diseases. Its detection still relies on traditional methods of analysis, such as gas and liquid chromatographies. Detection of free cholesterol in saliva with redox or enzymatic sensors or detection of lipoproteins in blood with aptamer sensors are currently the most
Jacopo Giaretta   +7 more
wiley   +1 more source

‘I, Me, Myself’: Selfhood and Melancholy in the Journals of Gertrude Savile (1697–1758)

open access: yesJournal for Eighteenth-Century Studies, EarlyView.
Abstract This article examines the journals of Gertrude Savile from 1727 in light of recent scholarship on early modern and eighteenth‐century melancholy. The concept had myriad associations with medicine, physiology, the imagination, and feeling, but questions remain about how melancholy during this period was considered by those outside the narrow ...
Daniel Beaumont
wiley   +1 more source

STUB1 (SCA48)/TBP (SCA17): A Frequent Association Still Not Fully Explained and a Lower Threshold for Intermediate Expanded TBP Alleles

open access: yes
Movement Disorders, EarlyView.
Cecilia Marelli   +10 more
wiley   +1 more source

Indigenous‐Led Adaptation to Complex Climate Risks in New Ireland, Papua New Guinea

open access: yesAsia Pacific Viewpoint, EarlyView.
ABSTRACT Pacific Island peoples have long histories of adapting to environmental changes, but recent climate change is now driving complex risks that unfold within rapidly shifting societal and environmental contexts. This study investigates how remote Indigenous communities in New Ireland, Papua New Guinea, experience and want to respond to complex ...
Eric Lede   +3 more
wiley   +1 more source

Information Discrimination and Its Implications on Distributing Healthcare Costs Fairly

open access: yesBioethics, EarlyView.
ABSTRACT When healthcare resources are scarce, they ought to be distributed fairly across society. For some theories of distribution, an assessment of individual health risk is required for a fair distribution of both healthcare resources and burdens. Despite this requirement, prevailing theories underappreciate the cost of information on health risk ...
Harisan U. Nasir
wiley   +1 more source

Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

open access: yesDisease Models & Mechanisms, 2022
Sai S. Pradhan   +11 more
doaj   +1 more source

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