Results 161 to 170 of about 9,130,139 (414)
Pediatric Neurology Briefs, 1993 The clinical manifestations, differential diagnosis, and treatment of benign hereditary chorea (BHC) are reviewed from the Indiana University and University of Minnesota Medical Schools.
J Gordon Millichap
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Impairment of consciousness in Alzheimer's disease: the amyloid water-filled nanotubes manifest quantum optical coherence interfering with the normal QBD? [PDF]
arXiv, 2002 Recent discovery by Perutz et al. of the physical structure of the amyloid that accumulates in neurons in certain neurodegenerative diseases like Alzheimer's disease or Huntington's disease, suggests novel mechanism of consciousness impairment, different from the neuronal loss, which is the end stage of the pathogenic process.
arxiv
Huntingtin suppression restores cognitive function in a mouse model of Huntington’s disease
Science Translational Medicine, 2018 Mutant huntingtin suppression with antisense oligonucleotides reverses cognitive impairments in a mouse model of Huntington’s disease. Rescuing cognition in Huntington’s disease Huntington’s disease (HD) is a neurodegenerative disorder caused by mutation
Amber L. Southwell +18 more
semanticscholar +1 more source
Astrocytes and Huntington’s Disease
ACS Chemical Neuroscience, 2014 In this Viewpoint, we summarize and discuss the recent serendipitous discovery of an astrocyte Kir4.1 potassium channel dysfunction in two mouse models of Huntington's disease (HD). Restoration of Kir4.1 channels within astrocytes in vivo attenuated neuronal dysfunction, some aspects of motor dysfunction and increased survival time in a HD mouse model.
Khakh, Baljit S, Sofroniew, Michael V
openaire +5 more sources
Environmental and Molecular Mutagenesis, EarlyView.Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons +17 more
wiley +1 more source
Binary and nonbinary description of hypointensity in human brain MR images [PDF]
arXiv, 2010 Accumulating evidence has shown that iron is involved in the mechanism underlying many neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and Huntington's disease. Abnormal (higher) iron accumulation has been detected in the brains of most neurodegenerative patients, especially in the basal ganglia region.
arxiv
Molecular diagnosis of Huntington disease in Brazilian patients [PDF]
, 2000 TEREZA C. LIMA E SILVA +3 more
openalex +1 more source
Differential loss of striatal projection neurons in Huntington disease.
Proceedings of the National Academy of Sciences of the United States of America, 1988 Huntington disease (HD) is characterized by the loss of striatal projection neurons, which constitute the vast majority of striatal neurons. To determine whether there is differential loss among different populations of striatal projection neurons, the ...
A. Reiner +5 more
semanticscholar +1 more source
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
Neuroacanthocytosis: A Case Report [PDF]
Türk Nöroloji Dergisi, 2006 The patient who had been treated symptomatically with the diagnosis of Huntington Disease was hospitalized in our clinic, got the diagnosis of neuroacanthocytosis with clinical findings and laboratory investigations was discussed in comparison with ...
Mustafa Yılmaz +4 more
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