Results 191 to 200 of about 9,130,139 (414)

Nutritional Outcomes in HPV‐Associated Oropharyngeal Squamous Cell Carcinoma After Transoral Robotic Surgery

The Laryngoscope, EarlyView.
This study evaluates how TORS, with or without adjuvant treatment, impacts swallowing and weight loss. Adjuvant treatment following TORS is associated with significantly greater long‐term weight loss but does not significantly alter swallowing outcomes. Longer duration of nasogastric tube dependence in the postoperative period is associated with higher
Vera Bzhilyanskaya, Jane Y. Tong, Matthew J. Ferris, Jason K. Molitoris, Kyle M. Hatten   +4 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

Mass Spectrometry Reviews, EarlyView.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu, Lawrence Abad, Lopamudra Chatterjee, Ileana M. Cristea, Markku Varjosalo   +4 more
wiley   +1 more source

Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

Disease Models & Mechanisms, 2022
Sai S. Pradhan, Sai M. Thota, Saiswaroop Rajaratnam, Sai K. S. Bhagavatham, Sujith K. Pulukool, Sriram Rathnakumar, Kanikaram S. Phalguna, Rajesh B. Dandamudi, Ashish Pargaonkar, Prasanth Joseph, E. V. Joshy, Venketesh Sivaramakrishnan   +11 more
doaj   +1 more source

Clinical and genetic study of a juvenile⁃onset Huntington disease

Chinese Journal of Contemporary Neurology and Neurosurgery, 2012
Background Huntington's disease (HD) is an autosomal dominant hereditary progressive neurodegenerative disorder with a distinct phenotype characterized by chorea, dementia, cognitive and affective impairment.
Ying HAO, Yuan⁃yuan CHEN, Wei⁃hong GU, Guo⁃xiang WANG, Hui⁃zi MA, Li⁃lin LI, Kang WANG, Miao JIN, Xiao⁃hui DUAN   +8 more
doaj  

Diagnosis of Huntington Disease [PDF]

, 2003
Russell L. Margolis, Christopher A. Ross
openalex   +1 more source

Reported Symptoms in Prodromal and Early Motor Parkinson's Disease: A Scoping Review on the Patient Perspective

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The lived experience of Parkinson's disease (PD) includes motor and non‐motor symptoms. There is a need to capture the earliest patient experiences in a sensitive and reliable manner for the successful development of interventions that may delay clinical progression in PD.
Joseph Saade, Alice van Wyk, Glenn T. Stebbins, Tiago A. Mestre   +3 more
wiley   +1 more source

AAV-Mediated gene delivery of BDNF or GDNF is neuroprotective in a model of huntington disease [PDF]

, 2004
Adrian P. Kells, Dahna M. Fong, Mike Dragunow, Matthew J. During, Deborah Young, Bronwen Connor   +5 more
openalex   +1 more source

Rodent genetic models of Huntington disease

Neurobiology of Disease, 2008
Huntington disease (HD) is a dominantly inherited human neurodegenerative disorder characterized by motor deficits, cognitive impairment, and psychiatric symptoms leading to inexorable decline and death.
Mary Y. Heng, Peter J. Detloff, Roger L. Albin   +2 more
doaj  

The CAG repeat at the Huntington disease gene in the Portuguese population: insights into its dynamics and to the origin of the mutation [PDF]

, 2005
Maria do Carmo Costa, Paula Magalhães, Laura Guimarães, Patrı́cia Maciel, Jorge Sequeiros, Alda Sousa   +5 more
openalex   +1 more source

Multiple discrete soluble aggregates influence polyglutamine toxicity in a Huntington\u27s disease model system [PDF]

, 2016
Huntington’s disease (HD) results from expansions of polyglutamine stretches (polyQ) in the huntingtin protein (Htt) that promote protein aggregation, neurodegeneration, and death.
Denis, Clyde L., Wang, Xin, Xi, Wen
core   +1 more source