Results 201 to 210 of about 127,473 (295)

Psychological care for Huntington's disease: A qualitative study exploring interventions in the Netherlands

Psychology and Psychotherapy: Theory, Research and Practice, Volume 99, Issue 2, Page 443-462, June 2026.
Abstract Objectives Huntington's disease (HD) is a hereditary neurodegenerative disorder characterized by a range of motor, cognitive, and psychiatric symptoms. Psychological symptoms can arise from being at risk for the disease and from its manifestation, necessitating psychological interventions to address the evolving burden, even before onset. This
Kasper F. Van der Zwaan, Laura C. M. Kuijper, Pearl J. C. van Lonkhuizen, Raymund A. C. Roos, Susanne T. de Bot   +4 more
wiley   +1 more source

Improving the Clinical Diagnostic Criteria for Genetically Confirmed Adult-Onset Huntington Disease: Considering Nonmotor Presentations. [PDF]

Neurol Clin Pract
Considine CM, Eddy CM, Frank SA, Kostyk SK, Oosterloo M, Killoran A, Furr Stimming E, Dose M, Cruickshank T, Bird TD, Vetter L, Arnesen A, Valvano J, Lange HW, Claassen DO.   +14 more
europepmc   +1 more source

Unraveling the Dynamics of Oxytocin in Hypothalamic Neurons

Traffic, Volume 27, Issue 2, June 2026.
Oxytocin (OT) plays an important role in regulating social behavior, and dysregulation of the oxytocinergic system leads to social impairments, such as autism spectrum disorder. Central OT release is poorly understood. Using live‐cell imaging to track vesicle trajectories, combined with machine learning‐based classification, the analysis reveals ...
Beatriz Aznar‐Escolano, Vera Egorova, José Villanueva, Luis Miguel Gutiérrez, Virginia González‐Vélez, Amparo Gil, Sandra Jurado   +6 more
wiley   +1 more source

Correction: Safety of Deutetrabenazine for the Treatment of Tardive Dyskinesia and Chorea Associated with Huntington Disease. [PDF]

Neurol Ther
Frank S, Anderson KE, Fernandez HH, Hauser RA, Claassen DO, Stamler D, Factor SA, Jimenez-Shahed J, Barkay H, Wilhelm A, Alexander JK, Chaijale N, Barash S, Savola JM, Gordon MF, Chen M.   +15 more
europepmc   +1 more source

Structural and Dynamics Insights into Melatonin Binding to MT1 Receptor

ChemBioChem, Volume 27, Issue 10, 27 May 2026.
In this study, we describe the structural and dynamic determinants governing MT1 binding by melatonin (MLT) by using an integrated approach that relies on the combination of on‐cell membrane nuclear magnetic resonance structural data with computational techniques.
Clementina Acconcia, Antonella Paladino, Francesca Scebba, Maria della Valle, Martina Montebuglio, Gaetano Malgieri, Carla Isernia, Roberto Fattorusso, Debora Angeloni, Stefano Comai, Luigi Russo   +10 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, Volume 13, Issue 5, Page 911-923, May 2026.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Early Diagnosis of Huntington Disease: Insights from Magnetic Resonance Spectroscopy-A Systematic Review. [PDF]

J Clin Med
Martínez Lozada PS, Duque Perez J, Celi Salinas R, Miranda Morales B, Pazmiño Mesías JF, García Ríos CA, Rodas JA, Leon-Rojas JE.   +7 more
europepmc   +1 more source

From Spider Webs to Brains: Can the Bri2 BRICHOS Molecular Chaperone Domain Transport Biological Drugs Into the Central Nervous System?

Advanced Biology, Volume 10, Issue 5, May 2026.
This Perspective describes how the chaperone‐like domain BRICHOS from the Bri2 protein is found to be transported across brain vascular endothelial cells and into neurons in the central nervous system. The possibility that Bri2 BRICHOS can be used as a transport shuttle for biological drugs into the CNS is discussed.
Cloé Moëlo, Nina Kronqvist, Jan Johansson   +2 more
wiley   +1 more source

Home cage-based insights into motor learning and strategy adaptation in a Huntington disease mouse model. [PDF]

PLoS One
Ramandi D, Sepers MD, Wang Z, Han B, Woodard CL, Murphy TH, Raymond LA.   +6 more
europepmc   +1 more source

Nanodiamond‐Based Quantum Sensing Reveals Changes in Endo‐Lysosomal Activity of Stimulated Cardiac Fibroblasts in a Cellular Fibrosis Model

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk, Ezgi Yilmaz, Giovanni D Angelo, Kirstine Berg‐Sørensen   +3 more
wiley   +1 more source