Results 201 to 210 of about 39,354 (231)
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Huntington's disease: Brain imaging in Huntington's disease
2019Huntington's disease (HD) gene-carriers show prominent neuronal loss by end-stage disease, and the use of magnetic resonance imaging (MRI) has been increasingly used to quantify brain changes during earlier stages of the disease. MRI offers an in vivo method of measuring structural and functional brain change. The images collected via MRI are processed
Eileanoir B, Johnson, Sarah, Gregory
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Apoptosis in Huntington's disease
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2003Huntington's disease (HD) is an autosomal dominant, fatal disorder. Patients display increasing motor, psychiatric and cognitive impairment and at autopsy, late-stage patient brains show extensive striatal (caudate and putamen), pallidal and cortical atrophy.
Miriam A, Hickey +1 more
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Huntington's disease of early onset or juvenile Huntington's disease
Hospital Medicine, 2003The presentation of juvenile Huntington's disease can cause diagnostic difficulties. The genetics and pathogenesis of the condition are discussed. The diagnosis will depend on the symptoms raising suspicions and the exclusion of other disorders, especially by genetic studies.
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2001
Huntington’s disease is a devastating autosomal-dominant neurodegenerative condition caused by the abnormal expansion of a polyglutamine tract in the huntingtin protein. Its epidemiology and clinical features are reviewed. A range of possible mechanisms for the disease is discussed and treatment prospects considered.
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Huntington’s disease is a devastating autosomal-dominant neurodegenerative condition caused by the abnormal expansion of a polyglutamine tract in the huntingtin protein. Its epidemiology and clinical features are reviewed. A range of possible mechanisms for the disease is discussed and treatment prospects considered.
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Genetics of Huntington disease
2017In this chapter, we review the evolution of our understanding of the genetic aspects of HD, and the applications of our understanding in the management of Huntington's disease patients and families over the last 150 years. Important aspects of the clinical genetics and epidemiology of Huntington's disease are discussed, such as the definition of ...
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Continuum
This article presents a systematic approach to the diagnosis and management of choreiform disorders, focusing on Huntington disease (HD) as a model.The availability of genetic testing and imaging biomarkers has led to changes in the definition of HD, which has shifted toward pathologic instead of clinical markers.
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This article presents a systematic approach to the diagnosis and management of choreiform disorders, focusing on Huntington disease (HD) as a model.The availability of genetic testing and imaging biomarkers has led to changes in the definition of HD, which has shifted toward pathologic instead of clinical markers.
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Therapeutic approaches to Huntington disease: from the bench to the clinic
Nature Reviews Drug Discovery, 2018Nicholas S Caron, , Michael R Hayden
exaly