Results 191 to 200 of about 39,354 (231)
Some of the next articles are maybe not open access.
Annual Review of Medicine, 1975
Huntington'S disease (HD) is an autosomal dominant disorder associated with neuronal degeneration especially involving the basal ganglia and cerebral cortex. The cardinal signs of dementia and involuntary movements usually appear in middle life. Although the pathogenesis of this disease remains unknown, its course progres sive, and the efficacy of ...
I, Shoulson, T N, Chase
openaire +2 more sources
Huntington'S disease (HD) is an autosomal dominant disorder associated with neuronal degeneration especially involving the basal ganglia and cerebral cortex. The cardinal signs of dementia and involuntary movements usually appear in middle life. Although the pathogenesis of this disease remains unknown, its course progres sive, and the efficacy of ...
I, Shoulson, T N, Chase
openaire +2 more sources
Current Treatment Options in Neurology, 2000
Huntington's disease is a neurodegenerative disorder inherited in an autosomal dominant fashion that results in involuntary movements, psychiatric symptoms, and cognitive dysfunction. The illness typically begins in midlife and progresses over 15 to 20 years, producing increasing disability.
, Haskins, , Harrison
openaire +2 more sources
Huntington's disease is a neurodegenerative disorder inherited in an autosomal dominant fashion that results in involuntary movements, psychiatric symptoms, and cognitive dysfunction. The illness typically begins in midlife and progresses over 15 to 20 years, producing increasing disability.
, Haskins, , Harrison
openaire +2 more sources
Psychiatric Clinics of North America, 1997
Huntington's disease is a genetically inherited degenerative neuropsychiatric disorder, characterized by motor alterations, including involuntary movements such as chorea, dementia and psychiatric disturbances. In this article, the authors review the clinical features of the disease. They also analyze some genetic and pathophysiologic aspects, that can
M S, Haddad, J L, Cummings
openaire +2 more sources
Huntington's disease is a genetically inherited degenerative neuropsychiatric disorder, characterized by motor alterations, including involuntary movements such as chorea, dementia and psychiatric disturbances. In this article, the authors review the clinical features of the disease. They also analyze some genetic and pathophysiologic aspects, that can
M S, Haddad, J L, Cummings
openaire +2 more sources
Current Treatment Options in Neurology, 2006
Although available treatments for Huntington's disease (HD) are imperfect, thoughtful application can positively impact quality of life. Dopamine antagonists can provide control of the troublesome hyperkinetic movements. These agents can also diminish the frequency of hallucinations and delusions when symptoms of psychosis occur. Classical neuroleptics
openaire +2 more sources
Although available treatments for Huntington's disease (HD) are imperfect, thoughtful application can positively impact quality of life. Dopamine antagonists can provide control of the troublesome hyperkinetic movements. These agents can also diminish the frequency of hallucinations and delusions when symptoms of psychosis occur. Classical neuroleptics
openaire +2 more sources
2018
Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive symptoms that progress over 15-20 years. Since the identification of the causative genetic mutation in 1993 much has been discovered about the underlying pathogenic mechanisms,
Rhia, Ghosh, Sarah J, Tabrizi
openaire +2 more sources
Huntington disease is a monogenic neurodegenerative disorder that displays an autosomal-dominant pattern of inheritance. It is characterized by motor, psychiatric, and cognitive symptoms that progress over 15-20 years. Since the identification of the causative genetic mutation in 1993 much has been discovered about the underlying pathogenic mechanisms,
Rhia, Ghosh, Sarah J, Tabrizi
openaire +2 more sources
Irritability in Huntington’s disease
Psychiatry Research, 2012Irritability is a frequent neuropsychiatric symptom in patients with Huntington's disease (HD). The Irritability Scale (IS) and the irritability factor of the Problem Behaviours Assessment (PBA) was used to assess irritability among 130 HD mutation carriers and 43 verified non-carriers. The IS was tested using receiver operating characteristic analysis
Reedeker, N. +6 more
openaire +3 more sources
Care Management Journals, 2008
Huntington's disease (HD) is a hereditary neurodegenerative disorder involving slow, progressive loss of functional capacities. Motor, psychiatric, and cognitive deterioration interfere with activities of independent living, gait, speech, and, ultimately, swallowing.
openaire +2 more sources
Huntington's disease (HD) is a hereditary neurodegenerative disorder involving slow, progressive loss of functional capacities. Motor, psychiatric, and cognitive deterioration interfere with activities of independent living, gait, speech, and, ultimately, swallowing.
openaire +2 more sources
2012
Huntington’s disease (HD) is an autosomal dominantly inherited, fatal neurodegenerative disorder, named for George Huntington, the author of the first definitive report of the condition in 1872. It is characterized by the progressive development of involuntary choreiform movements, although neuropsychiatric symptoms are sometimes the earliest and often
Raphael M, Bonelli, M Flint, Beal
openaire +2 more sources
Huntington’s disease (HD) is an autosomal dominantly inherited, fatal neurodegenerative disorder, named for George Huntington, the author of the first definitive report of the condition in 1872. It is characterized by the progressive development of involuntary choreiform movements, although neuropsychiatric symptoms are sometimes the earliest and often
Raphael M, Bonelli, M Flint, Beal
openaire +2 more sources
The American Journal of Nursing, 1979
ted by both sexes. Each child of an afflicted parent has a 50 percent chance of inheriting the disease. This risk continues uninterrupted from one generation to the next. Occasionally, a parent dies before the age when the symptoms characteristically appear, and this may give the impression, incorrectly, that Huntington's disease has skipped a ...
J, Stipe, D, White, E, Van Arsdale
openaire +2 more sources
ted by both sexes. Each child of an afflicted parent has a 50 percent chance of inheriting the disease. This risk continues uninterrupted from one generation to the next. Occasionally, a parent dies before the age when the symptoms characteristically appear, and this may give the impression, incorrectly, that Huntington's disease has skipped a ...
J, Stipe, D, White, E, Van Arsdale
openaire +2 more sources
The Enigma of Huntington's Disease
Scientific American, 2002A description of huntingtons disease and the gene which is responsible for it is presented. Huntingtons disease, which cripples and causes dementia is a genetic disease that results from a mutation in a gene called huntingtin found on chromosome 4. Mutant hutingtin appears to be toxic to key nerve cells in the brain and lacks the ability to turn on a ...
E. Cattaneo, D. Rigamonti, C. Zuccato
openaire +2 more sources