Results 221 to 230 of about 127,473 (295)

On Making Descendant Communities: Three Case Studies From Historical Bioarchaeology

American Journal of Biological Anthropology, Volume 190, Issue 1, May 2026.
ABSTRACT Bioarchaeologists, museums and universities, journal editorial boards, and academic professional organizations are working toward ethical engagements with human remains, with a focus on descendant community engagement. This article reexamines past and present bioarchaeological descendant community engagement to consider how “descendant ...
Alanna L. Warner‐Smith, Lauren R. Hosek, Meredith A. B. Ellis   +2 more
wiley   +1 more source

Atypical Presentations of Huntington Disease-like 2 in South African Individuals. [PDF]

Mov Disord Clin Pract
Narotam-Jeena H, Guttman M, van Hillegondsberg L, van Coller R, Krause A, Carr J.   +5 more
europepmc   +1 more source

Metabolomic ageing (MileAge) in mid‐life predicts incident vascular, unspecified and all‐cause dementia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Identifying individuals at risk of dementia is essential for prevention and targeted disease‐modifying strategies. We investigated whether mid‐life metabolomic ageing is associated with incident dementia and its age of onset and assessed joint associations and interactions with APOE genotype and dementia polygenic scores.
Julian Mutz, Lachlan Gilchrist, Oliver Pain, Petroula Proitsi, Cathryn M. Lewis   +4 more
wiley   +1 more source

Digital assessment of speech in Huntington disease. [PDF]

Front Neurol
Nunes AS, Pawlik M, Mishra RK, Waddell E, Coffey M, Tarolli CG, Schneider RB, Dorsey ER, Vaziri A, Adams JL.   +9 more
europepmc   +1 more source

circPDE4B downregulation triggers GEMIN5‑dependent translational stress response and autophagy to reduce MAPT pathology

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Circular RNAs (circRNAs) are emerging as key regulators of gene expression, synaptic plasticity, and neuronal function in Alzheimer's disease (AD). Here, we characterize the biological actions of circPDE4B, a highly expressed circRNA markedly reduced in AD. METHODS circPDE4B knockdown in neuronal progenitor cells was combined with
Sambhavi Puri, Sophie J. F. van der Spek, Mintao Lin, Zihan Wang, Jacob Porter, Junming Hu, Liyuan Hu, Alejandro N. Rondón‐Ortiz, Alexander Knyshov, Jenna L. Libera, Scott E. Counts, Debomoy K. Lahiri, Julia TCW, Andrew Emili, Xiaoling Zhang, Benjamin Wolozin   +15 more
wiley   +1 more source

Safety and Efficacy of Deutetrabenazine at High versus Lower Daily Dosages in the ARC-HD Study to Treat Chorea in Huntington Disease. [PDF]

CNS Drugs
Frank S, Testa CM, Goldstein J, Kayson E, Leavitt BR, Oakes D, O'Neill C, Whaley J, Gross N, Chaijale N, Barash S, Gordon MF, Huntington Study Group/ARC-HD Investigators and Coordinators.   +12 more
europepmc   +1 more source

Speech‐based digital cognitive assessment for clinical trials: Detecting cognitive impairment stages and AD biomarker relations across European cohorts

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Early detection of Alzheimer's disease (AD) is critical for timely intervention as disease‐modifying treatments emerge. Speech‐based digital biomarkers offer scalable options for remotely capturing speech‐derived functional changes associated with early cognitive decline, but validation across real‐world populations remains ...
Alexandra König, Johannes Tröger, Elisa Mallick, Nicklas Linz, Craig Ritchie, Sarah Gregory, Matthew Hunter, Kay Johnson, Gonzalo Sánchez Benavides, Oriol Grau‐Rivera, Andreea Radoi, Claudia Porta‐Mas, Stefanie Köhler, Stefan Teipel, Oskar Hansson, Pontus Tideman, Anika Wuestefeld, Sebastian Palmqvist   +17 more
wiley   +1 more source

Racial Disparities in Time to Huntington Disease Diagnosis in North America: An ENROLL-HD Analysis. [PDF]

Neurol Clin Pract
Mendizabal A, Ogilvie AC, Bordelon Y, Perlman SL, Brown A.   +4 more
europepmc   +1 more source

Causal Links of Type 2 Diabetes and Its Complications With Cortical Modification: A Mendelian Randomization and Mediation Analysis

Brain and Behavior, Volume 16, Issue 5, May 2026.
Mendelian randomization (MR) analyses revealed significant causal associations between T2DM (including neurological, ophthalmic, renal, and peripheral circulatory complications) and alterations in total cortical surface area, average cortical thickness, as well as region‐specific surface area and thickness across 34 cortical subdivisions.
Hong Huang, Hanyu Huang, Yanlin Gong, Tengteng Zhou, Yundan Liang, Yichao Wang   +5 more
wiley   +1 more source